About Dr. Raghu Kalluri raghu kalluri

About Dr. Raghu Kalluri raghu kalluri

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Raghu Kalluri

Professor

  • Cancer Center Support Grant (CCSG) Programs
  • Cancer Biology
  • Graduate School of Biomedical Sciences
  • 6767 Bertner Ave, Mitchell Basic Science Research Building

    77030 Houston

    United States


  • 40084
    Citations

  • 95
    h-Index
1991 …2018

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Research Output

1991


2018

  • 40084
    Citations
  • 95
    h-Index

  • 205

    Article

  • 46

    Review article

  • 13

    Comment/debate

  • 9

    Short survey
  • 13

    More


    • 6 Editorial

    • 5 Chapter

    • 2 Letter

Research Output per year

6
Citations

A peek into cancer-associated fibroblasts: Origins, functions and translational impact

LeBleu, V. S. & Kalluri, R. , Apr 1 2018, In : DMM Disease Models and Mechanisms. 11, 4, 029447

Research output: Contribution to journalArticle


Neoplasms


Fibroblasts


Cancer-Associated Fibroblasts


Posters


Tumor Microenvironment

3
Citations

Consensus guidelines for the use and interpretation of angiogenesis assays

Nowak-Sliwinska, P. , Alitalo, K. , Allen, E. , Anisimov, A. , Aplin, A. C. , Auerbach, R. , Augustin, H. G. , Bates, D. O. , van Beijnum, J. R. , Bender, R. H. F. , Bergers, G. , Bikfalvi, A. , Bischoff, J. , Böck, B. C. , Brooks, P. C. , Bussolino, F. , Cakir, B. , Carmeliet, P. , Castranova, D. , Cimpean, A. M. & 66 others Cleaver, O., Coukos, G., Davis, G. E., De Palma, M., Dimberg, A., Dings, R. P. M., Djonov, V., Dudley, A. C., Dufton, N. P., Fendt, S. M., Ferrara, N., Fruttiger, M., Fukumura, D., Ghesquière, B., Gong, Y., Griffin, R. J., Harris, A. L., Hughes, C. C. W., Hultgren, N. W., Iruela-Arispe, M. L., Irving, M., Jain, R. K., Kalluri, R. , Kalucka, J., Kerbel, R. S., Kitajewski, J., Klaassen, I., Kleinmann, H. K., Koolwijk, P., Kuczynski, E., Kwak, B. R., Marien, K., Melero-Martin, J. M., Munn, L. L., Nicosia, R. F., Noel, A., Nurro, J., Olsson, A. K., Petrova, T. V., Pietras, K., Pili, R., Pollard, J. W., Post, M. J., Quax, P. H. A., Rabinovich, G. A., Raica, M., Randi, A. M., Ribatti, D., Ruegg, C., Schlingemann, R. O., Schulte-Merker, S., Smith, L. E. H., Song, J. W., Stacker, S. A., Stalin, J., Stratman, A. N., Van de Velde, M., van Hinsbergh, V. W. M., Vermeulen, P. B., Waltenberger, J., Weinstein, B. M., Xin, H., Yetkin-Arik, B., Yla-Herttuala, S., Yoder, M. C. & Griffioen, A. W., Aug 1 2018, In : Angiogenesis. 21, 3, p. 425-532 108 p.

Research output: Contribution to journalReview article


Biological Assay


Guidelines


Growth and Development


Blood Vessels


Regeneration

Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program

Chen, Y., LeBleu, V. S., Carstens, J. L. , Sugimoto, H., Zheng, X. , Malasi, S., Saur, D. & Kalluri, R. , Oct 1 2018, In : EMBO Molecular Medicine. 10, 10, e9085

Research output: Contribution to journalArticle


Epithelial-Mesenchymal Transition


Genetic Models


Pancreatic Neoplasms


Neoplasm Metastasis


Neoplasms

48
Citations

EMT in cancer

Brabletz, T., Kalluri, R. , Nieto, M. A. & Weinberg, R. A., Jan 25 2018, In : Nature Reviews Cancer. 18, 2, p. 128-134 7 p.

Research output: Contribution to journalReview article


Epithelial-Mesenchymal Transition


Neoplasms


Embryonic Development


Cell Culture Techniques


Research Personnel

Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition

Lovisa, S. & Kalluri, R. , May 1 2018, In : Trends in Molecular Medicine. 24, 5, p. 432-434 3 p.

Research output: Contribution to journalShort survey


Fatty Acids


Endothelial Cells


Cellular Reprogramming

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MD Anderson Cancer Center – UTHealth
Graduate School of Biomedical Sciences

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Dr. Raghu Kalluri

Dr. Raghu Kalluri

Regular Member

Professor

The University of Texas MD Anderson Cancer Center
Department of Cancer Biology

Functional parenchymal cells can acquire genetic defects (gene mutations, deletions, etc) and generate what are known as cancer cells. Such cancer cells experience enhanced proliferation associated with increased rate of DNA replication, oxygen and metabolic adaptions to survive and multiply. When a normal cell behaves abnormally (such as a cancer cell), our body is designed to sense this ‘damage’ and initiate host response to repair and regenerate the tissue, and restore organ homeostasis. If repair by our body is successful, abnormal parenchymal cells (cancer cells) are destroyed and eliminated. Arguably, such damage and repair is constantly occurring in our body to maintain organ health and not noticed. On the other hand, if repair and regenerative events are not optimal, early cancer lesions are not completely eliminated but due to successful host injury response, get contained and remain as dormant, non-invasive in situ cancers. Such small cancer lesions could remain in such a dormant state for the lifespan of an individual. Autopsy studies have clearly demonstrated that a large majority of people over the age of 50 may likely have dormant cancer lesions, in some tissue or other, with identifiable cancer driving genetic defects. It is possible that about 750 million people worldwide are living with such dormant cancer lesions. Emergence of malignant cancer and metastasis may occur over a period of 20 years. It is conceivable in such cases that cancer cell defects ultimately overcome the host defenses and breakthrough to win the battle towards malignancy. Our laboratory is interested in elucidating the governing principles that determine how cancer initiates and progresses towards malignancy. We are investigating how cancer genotype influences host responses, leading to a complex tumor microenvironment and tumor immunity. Employing comprehensive cancer genomics, single cell sequencing, novel genetic mouse models and functional dissection of stromal heterogeneity of tumor microenvironment, we are investigating novel mechanisms associated with cancer progression and metastasis. Such basic science efforts are coupled to tangible translational outputs, facilitating discovery of new therapeutic targets and novel drug development strategies.

Graduate student training in the Kalluri Laboratory:

The Kalluri laboratory has trained 13 graduate PhD students and 31 graduate PhD students conducted rotation research projects in the laboratory. Fourteen medical students conducted research in the laboratory via various fellowships including the HHMI medical student research fellowships. The laboratory was also a research training ground for 33 undergraduate and high school students.

Research discoveries by our graduate PhD students led to clinical trials and collaborations with many academic laboratories and biopharmaceutical companies. Teamwork and integrity is central to our laboratory research culture. Graduate students are encouraged to develop independent projects and pursue their passion for research. They are also encouraged to conduct paradigm-shifting research that can bring forward new basic science discoveries and help our patients. Graduate students are supported and mentored directly by the PI, as well as provided with hands-on training and supervision by the senior fellows and other technology experts in the laboratory. The laboratory is an inter-dependent team and a science family that works diligently to help one another and foster laboratory collaborations. Graduate students are encouraged to learn freely and identify a project of their interest, and pursue their thesis work with direct supervision and training from the PI and all members of the laboratory.

Kalluri Lab

PubMed

MDACC Faculty

Kalluri Lab

Contact Information

Phone: 713.792.8733

Email: [email protected]

Office: MDA 3SCR5.3414 (Unit 1906)

Education:

Ph.D. – University of Kansas Medical Center – 1992
M.D. – Brown University School of Medicine – 2009 

Programs:

  • Cancer Biology
  • Genetics and Epigenetics

Faculty is Currently:

  • Seeking MS Students
  • Seeking PhD Students

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