PCOS

What Is Hyperprolactinemia?

Abnormal hormonal function affects both women and men


By Nicole Galan, RN
Updated February 07, 2018
diagnosis and treatment hyperprolactemia

Ron Levine/Getty

More in PCOS

  • Symptoms & Causes

  • Diagnosis

  • Treatment

  • Living With

  • Support & Coping

  • Nutrition & Weight Loss

  • Fertility

  • Related Conditions

Hyperprolactinemia is a state characterized by high levels of a hormone called prolactin in the blood. Prolactin is produced by the pituitary gland and plays a vital role in the development of the breasts during pregnancy.

While hyperprolactinemia is considered perfectly normal during pregnancy and breastfeeding, it can occur at other times due to disease and medication use. Hyperprolactinemia can affect both woman and men, resulting in irregular menstrual periods and erectile dysfunction, among other things.

Causes of Hyperprolactinemia

Prolactin levels may be elevated for any number of reasons. One of the more common cause is the formation of a benign tumor on the pituitary gland. This noncancerous growth, known as a prolactinoma, directly secretes excessive prolactin while decreasing the levels of other sex hormones.

Diseases affecting a portion of the brain called the hypothalamus can also cause hyperprolactinemia. The hypothalamus functions as the link between the nervous system and the pituitary gland. The increase in prolactin levels can often be directly linked to a tumor, trauma, or infection of the hypothalamus.

Other causes may include:

  • Hypothyroidism (low thyroid hormone levels)
  • Cirrhosis of the liver
  • Chronic kidney failure
  • Antidepressants (Anafranil, Norpramin)
  • Antipsychotics (Haldol, Zyprexa, Risperdal)
  • Antihypertensives ( Verelan, Calan, Covera-HS, Isoptin)
  • Antinauseals (Reglan, Primperan, Lexapram)
  • Acid H2 blockers (Tagamet, Zantac)
  • Estrogen

Symptoms of Hyperprolactinemia

The symptoms of hyperprolactinemia in women can vary. When occurring outside of pregnancy or breastfeeding, they may include:

  • Infertility
  • Gallactoria (abnormal lactation)
  • Infrequent or irregular periods
  • Amenorrhea (disappearance of ovulation periods)
  • Loss of libido
  • Breast pain
  • Painful intercourse due to vaginal dryness

When occurring in men, the symptoms typically involve sexual dysfunction and/or pain associated with the formation of the prolactinoma. Common signs and symptoms include:

  • Erectile dysfunction
  • Gynecomastia (development of breast tissue)
  • Lactation
  • Infertility
  • Loss of libido

Because hyperprolactinemia in men does not always manifest with overt symptoms, such as menstrual problems, it is sometimes difficult to spot. In some cases, headaches caused by the pituitary tumor or changes in vision may be the first sign of the condition in both men and women.

Diagnosis of Hyperprolactinemia

The diagnosis of hyperprolactinemia involves a routine blood test to check prolactin levels. If the blood levels are elevated, the doctor may want to repeat the test, this time after fasting for at least eight hours. Normal prolactin levels are less than 500 mIU/L for women and less than 450 mIU/L for men

A magnetic resonance imaging (MRI) scan may be ordered to look for evidence of a pituitary growth or for damage to surrounding tissues. Blood tests to evaluate other hormone levels may be useful in ruling out any other possible causes of the symptoms.

Treatment of Hyperprolactinemia

The goal of treatment is to return prolactin to normal levels. There are a number of standard options to achieve this:

  • The medications Parlodel (bromocriptine) and Dostinex (cabergoline) are known to be effective in reducing prolactin levels and shrinking pituitary tumors.
  • Surgery may sometimes be used to remove a pituitary tumor if the medications are not working or are poorly tolerated
  • Radiation, while rarely used, may be suggested if the medicines and surgery have not been effective.
  • Hypothyroidism can be treated with synthetic thyroid hormone, which should bring prolactin levels down.
  • If high prolactin levels are caused by prescription drugs, substitute medications may be prescribed.
Was this page helpful?


Thanks for your feedback!
What are your concerns?



Article Sources





  • Melmed, S.; Casanueva, F.; Hoffman, A. et al. ” Diagnosis and Treatment of Hyperprolactinemia : An Endocrine Society Clinical Practice Guideline.” Journal of Clinical Endocrinology and Metabolism. 2011; 96(2):272-88.

  • Blood test tubes

    Article

    How High Prolactin Levels Can Cause Different Diseases

  • conditions similar to PCOS

    Article

    How Is PCOS Diagnosed?

  • Brain

    Article

    Cushing’s Syndrome and How To Treat It

  • Nurse taking blood from patient, close up

    Article

    What Lab Tests Do I Need When My Doctor Suspects PCOS?

  • woman shaving face in mirror

    Article

    When PCOS Is the Underlying Cause of Excess Facial Hair

  • Female doctor checking patient's neck

    Article

    Are My Symptoms Related to PCOS or Thyroid Disease?

  • Polycystic ovary syndrome, illustration

    Article

    If You Have PCOS, You May Have Insulin Resistance Too

  • Teen Girl

    Article

    Answers for Teens With PCOS

  • Woman using acne cleaning pad to wash face

    Article

    Androgens & PCOS: Excess Levels & What It Means

  • Female hormone system

    Article

    What Is the Endocrine System and How Does It Work?

  • Woman running to toilet in night clothes

    Article

    What’s the Link Between Antidiuretic Hormone (ADH) and PCOS?

  • Woman and PCOS

    Article

    Causes of Polycystic Ovarian Syndrome

  • Beautiful girl sitting pensively holding her legs in bedroom.

    Article

    How Can You Cope With the Symptoms of PCOS?

  • Ovulation

    Article

    Here Is What to Know About Follicle Stimulating Hormone (FSH)

  • exercise during fertility treatments

    Article

    Learn About Exercising During Fertility Treatment for PCOS

  • Woman breastfeeding her baby

    Article

    Can a Woman With PCOS Breastfeed Her Baby?