Trazodone Is trazodone a barbiturate

Trazodone Is trazodone a barbiturate


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Trazodone

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Trazodone
Trazodone.svg
Trazodone-from-HCl-xtal-3D-balls.png
Clinical data
Trade names Many brand names worldwide [1]
SynonymsAF-1161
AHFS / Drugs.com Monograph
MedlinePlus a681038
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
By mouth ( tablets )
ATC code
  • N06AX05 ( WHO )
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability By mouth : 65% [3]
Protein binding 89–95% [4]
Metabolism Liver ( CYP3A4 ) [2]
Metabolites mCPP [5]
Onset of action By mouth : 1 hour ( Tmax ) [6]
Elimination half-life Trazodone IR: 7 hours [3]
Trazodone ER: 10 hours [3]
mCPP : 4–8 hours [7]
Excretion Urine : 70–75% [3]
Feces : 21% [3]
Identifiers
IUPAC name
  • 2-3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
CAS Number
  • 19794-93-5  ☑Y
PubChem CID
  • 5533
IUPHAR/BPS
  • 213
DrugBank
  • DB00656  ☑Y
ChemSpider
  • 5332  ☑Y
UNII
  • YBK48BXK30
KEGG
  • D08626  ☑Y
ChEBI
  • CHEBI:9654  ☑Y
ChEMBL
  • CHEMBL621  ☑Y
ECHA InfoCard 100.039.364 Edit this at Wikidata
Chemical and physical data
Formula C19H22ClN5O
Molar mass 371.8641 g/mol
3D model ( JSmol )
  • Interactive image
SMILES
  • Clc4cccc(N3CCN(CCCN1/N=C2/C=C\C=C/N2C1=O)CC3)c4
InChI
  • InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2 ☑Y
  • Key:PHLBKPHSAVXXEF-UHFFFAOYSA-N ☑Y

   (verify)

Trazodone, sold under many brand names worldwide, [1] is an antidepressant medication. [8] It is used to treat major depressive disorder , anxiety disorders , and in addition to other treatment, alcohol dependence . [8] It is taken by mouth. [8]

Common side-effects include dry mouth, feeling faint, vomiting, and headache. [8] More serious side effects may include suicide , unmasking bipolar disorder , irregular heart rate , and pathologically prolonged erections . [8] It is unclear if use during pregnancy or breastfeeding is safe. [9] It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class. [10] [11] Trazodone also has sedating effects. [12]

Trazodone was approved for medical use in the United States in 1981. [8] It is available as a generic medication . [8] The cost in the United Kingdom for the NHS is about £21.23 per month as of 2015. [12] In the United States, the wholesale cost is about 4.53 USD per month as of 2018. [13] In 2014 about 26 million prescriptions for the medication were filled in the US. [14]

Contents

  • 1 Medical uses
    • 1.1 Depression
    • 1.2 Insomnia
    • 1.3 Non-approved uses
    • 1.4 Available forms
  • 2 Contraindications
    • 2.1 Pregnancy and lactation
    • 2.2 Occupational hazards
  • 3 Side effects
    • 3.1 Cardiac arrhythmia
    • 3.2 Priapism
    • 3.3 Other
  • 4 Overdose
  • 5 Interactions
  • 6 Pharmacology
    • 6.1 Pharmacodynamics
      • 6.1.1 Correspondence to clinical effects
    • 6.2 Pharmacokinetics
  • 7 Chemistry
  • 8 History
  • 9 Society and culture
    • 9.1 Generic names
    • 9.2 Brand names
  • 10 References
  • 11 External links

Medical uses[ edit ]

Trazodone has the following medical uses:

  • Unipolar depression , with or without anxiety [15]
  • Anxiety disorder [16]
  • Insomnia [17]

Depression[ edit ]

The primary use of trazodone is the treatment of major depression. Data from open and double-blind trials suggest the antidepressant efficacy of trazodone is comparable to that of amitriptyline , doxepin , and mianserin . Also, trazodone showed anxiolytic properties, low cardiotoxicity , and relatively mild side effects. [18]

Because trazodone has minimal anticholinergic activity, it was especially welcomed as a treatment for geriatric patients with depression when it first became available. Three double-blind studies reported trazodone has antidepressant efficacy similar to that of other antidepressants in geriatric patients. However, a side effect of trazodone, orthostatic hypotension , which may cause dizziness and increase the risk of falling, can have devastating consequences for elderly patients; thus, this side effect, along with sedation, often makes trazodone less acceptable for this population, compared with newer compounds that share its lack of anticholinergic activity but not the rest of its side-effect profile. Still, trazodone is often helpful for geriatric patients with depression who have severe agitation and insomnia. [18]

Insomnia[ edit ]

Many clinicians use low-dose trazodone as an alternative to benzodiazepines for the treatment of insomnia . Two recent reviews found that trazodone is the second most prescribed agent for insomnia , but as most studies have been limited to people with depression , few studies actually support trazodone’s use in primary insomnia. [18]

Non-approved uses[ edit ]

Off-label uses and investigational uses are listed below:

  • Complex regional pain syndrome [19]
  • Obsessive–compulsive disorder (OCD) [20]
  • Alcohol withdrawal [21] [22] [23]
  • Schizophrenia as an adjunct to improve negative symptoms [24]
  • Erectile dysfunction [25]

Available forms[ edit ]

Trazodone is available in the form of 50 mg, 100 mg, 150 mg, and 300 mg tablets for oral ingestion. [26] [27]

Contraindications[ edit ]

Contraindications and precautions for trazodone include:

  • If the patient has a known hypersensitivity to trazodone
  • If the patient is under 18 years of age and trazodone is combined with other antidepressant medications, it may increase the possibility of suicidal thoughts or actions. [28]

The possibility of suicide in depressed patients remains during treatment and until significant remission occurs. The number of tablets prescribed at any one time should take into account this possibility, and patients with suicidal ideation should never have access to large quantities of trazodone.

Trazodone has been reported to cause seizures in a small number of patients who took it concurrently with medications to control seizures.

While trazodone is not a true member of the SSRI class of antidepressants, it does still share many properties of the SSRIs, especially the possibility of discontinuation syndrome if the medication is stopped too quickly. [29] Care must, therefore, be taken when coming off the medication, usually by a gradual process of tapering down the dose over a period of time.

Pregnancy and lactation[ edit ]

Sufficient data in humans are lacking. Use should be justified by the severity of the condition to be treated. [30] [31]

Occupational hazards[ edit ]

Since trazodone may impair the mental and/or physical abilities required for performance of potentially hazardous tasks, such as operating an automobile or machinery, the patient should be cautioned not to engage in such activities while impaired.

Side effects[ edit ]

See also: List of adverse effects of trazodone

Because of its lack of anticholinergic side effects, trazodone is especially useful in situations in which antimuscarinic effects are particularly problematic (e.g., in patients with benign prostatic hyperplasia, closed-angle glaucoma, or severe constipation). Trazodone’s propensity to cause sedation is a dual-edged sword. For many patients, the relief from agitation, anxiety, and insomnia can be rapid; for other patients, including those individuals with considerable psychomotor retardation and feelings of low energy, therapeutic doses of trazodone may not be tolerable because of sedation. Trazodone elicits orthostatic hypotension in some patients, probably as a consequence of α1-adrenergic receptor blockade. Mania has been observed in association with trazodone treatment, including in patients with bipolar disorder, as well as in patients with previous diagnoses of major depression.
Compared to the reversible MAOI antidepressant drug moclobemide , significantly more impairment of vigilance occurs with trazodone. [32]

Cardiac arrhythmia[ edit ]

Case reports have noted cardiac arrhythmias emerging in relation to trazodone treatment, both in patients with pre-existing mitral valve prolapse and in patients with negative personal and family histories of cardiac disease. [33]

QT prolongation has been reported with trazodone therapy. Arrhythmia identified include isolated PVCs , ventricular couplets, and in two patients short episodes (three to four beats) of ventricular tachycardia. Several post-marketing reports have been made of arrhythmia in trazodone-treated patients who have pre-existing cardiac disease and in some patients who did not have pre-existing cardiac disease. Until the results of prospective studies are available, patients with pre-existing cardiac disease should be closely monitored, particularly for cardiac arrhythmias. Trazodone is not recommended for use during the initial recovery phase of myocardial infarction. Concomitant administration of drugs that prolong the QT interval or that are inhibitors of CYP3A4 may increase the risk of cardiac arrhythmia. [34] [35]

Priapism[ edit ]

A relatively rare, but dramatic, side effect associated with trazodone is priapism , likely due to its antagonism at α-adrenergic receptors. [36] More than 200 cases have been reported, and the manufacturer estimated that the incidence of any abnormal erectile function is about one in 6,000 male patients treated with trazodone. The risk for this side effect appears to be greatest during the first month of treatment at low dosages (i.e. <150 mg/day). Early recognition of any abnormal erectile function is important, including prolonged or inappropriate erections, and should prompt discontinuation of trazodone treatment. Clinical reports have also described trazodone-associated psychosexual side effects in women, including increased libido , priapism of the clitoris, and spontaneous orgasms . [33] [37]

Other[ edit ]

Rare cases of idiosyncratic liver toxicity have been observed, possibly due to the formation of reactive metabolites. [38]

Elevated prolactin concentrations have been observed in patients taking trazodone. [39]

Overdose[ edit ]

There are reported cases of high doses of trazodone precipitating serotonin syndrome . [40] There are also reports of patients taking multiple SSRIs with trazodone and precipitating serotonin syndrome. [41]

Trazodone appears to be relatively safer than TCAs , MAOIs , and a few of the other second-generation antidepressants in overdose situations, especially when it is the only agent taken. Fatalities are rare, and uneventful recoveries have been reported after ingestion of doses as high as 6,000–9,200 mg. In one report, 9 of 294 cases of overdose were fatal, and all nine patients had also taken other central nervous system (CNS) depressants. When trazodone overdoses occur, clinicians should carefully monitor for low blood pressure , a potentially serious toxic effect. In a report of a fatal trazodone overdose, torsades de pointes and complete atrioventricular block developed, along with subsequent multiple organ failure, with a trazodone plasma concentration of 25.4 mg/L on admission. [18] [42] [43] [44]

There is no specific antidote for trazodone. Management of overdosage should, therefore, be symptomatic and supportive. Any person suspected of having taken an overdosage should be evaluated at a hospital as soon as possible. Activated charcoal , and forced diuresis may be useful in facilitating elimination of the drug, gastric lavage has been shown to not be useful unless done during the first hour after intake.[ citation needed ]

Interactions[ edit ]

Trazodone is metabolized by CYP3A4 , a liver enzyme. [45] Inhibition of this enzyme by various other substances may delay its degradation, leading to high blood levels of trazodone. CYP3A4 may be inhibited by many other medications, herbs, and foods, and as such, trazodone may interact with these substances.

Pharmacology[ edit ]

Pharmacodynamics[ edit ]

Trazodone (and metabolite) [46]
SiteTrazodone mCPP SpeciesRef
SERT 160–>10,000 [47] 202–432Human [46] [48] [49]
NET ≥8,500≥1,940Human [49] [48]
DAT ≥7,400 NDHuman [49] [46]
5-HT1A 96–11844–400Human [46] [50] [51]
5-HT1B >10,00089–501Human [46] [52]
5-HT1D 106210–1,300Human [46] [51] [53]
5-HT1E >10,000 NDHuman [46]
5-HT1F ND ND ND ND
5-HT2A 20–4532–398Human [46] [54] [55] [56]
5-HT2B 74–1893.2–63Human [46] [54] [57] [58]
5-HT2C 224–4023.4–251Human [54] [59] [60] [56]
5-HT3 >10,000427Human [46]
5-HT4 ND ND ND ND
5-HT5A >10,0001,354Human [46]
5-HT6 >10,0001,748Human [46]
5-HT7 1,782163Human [46]
α1 12–4297–2,900Human [48] [50] [51] [61]
   α1A 1531,386Human [46]
   α1B ND915Human [46]
   α1D ND ND ND ND
α2 106–490112–570Human [50] [48] [51] [61]
   α2A 728145Human [46]
   α2B ND106Human [46]
   α2C 155124Human [46]
β >10,0002,500Human [46] [51]
   β1 >10,0002,359Human [46]
   β2 >10,0003,474Human [46]
D1 3,7307,000Human [46] [51]
D2 ≥3,500>10,000Human [46] [50] [62] [51]
D3 353>10,000Rat [46] [51]
D4 703 NDHuman [46]
D5 >10,000>10,000Human [46] [51]
H1 220–1,100326Human [46] [61] [50]
H2 3,290 NDHuman [46]
H3 >10,000 NDGuinea pig [46]
H4 >10,000 NDHuman [46]
mAChRs >10,000>10,000Human [46] [62] [50] [51]
nAChRs >10,000>10,000Human [46]
σ1 >10,000 NDRat [46]
σ2 5368,350Rat [46]
I1 ND759Rat [46]
NMDAR
(MK-801)
>10,000 NDRat [46]
VDCCs >10,0006,043Rat [46]
Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site.

Trazodone is generally described as acting as a potent serotonin 5-HT2A and α1-adrenergic receptor antagonist , a weak serotonin reuptake inhibitor (SRI), and a weak antihistamine or histamine H1 receptor inverse agonist . [63] Its 5-HT2A receptor antagonism and weak serotonin reuptake inhibition form the basis of its common label as a serotonin antagonist and reuptake inhibitor (SARI). [64] Trazodone, both itself and via its major active metabolite meta-chlorophenylpiperazine (mCPP), [65] also binds to a variety of other receptors. [46] It is an antagonist at most or all of the receptors it binds to except the 5-HT1A receptor , where it acts as a partial agonist similarly to buspirone and tandospirone but with comparatively greater intrinsic activity . [46] [66] [67] Conversely, mCPP is a non-selective agonist of most of the serotonin receptors it binds to. [68] A range of weak affinities (Ki) have been reported for trazodone at the human histamine H1 receptor including 220 nM, [46] 350 nM, [61] 500 nM, [69] and 1,100 nM. [50]

Correspondence to clinical effects[ edit ]

Trazodone acts predominantly as a 5-HT2A receptor antagonist to mediate its therapeutic benefits against anxiety and depression . [70] Its inhibitory effects on serotonin reuptake and 5-HT2C receptors are comparatively weak. [70] Hence, trazodone does not have similar properties to selective serotonin reuptake inhibitors (SSRIs) [70] and is not particularly associated with increased appetite and weight gain , unlike other 5-HT2C antagonists like mirtazapine . [71] [72] Moderate 5-HT1A partial agonism is likely to contribute to trazodone’s antidepressant and anxiolytic actions to some extent as well. [66] [67] [73]

The combined actions of 5-HT2A and 5HT2C receptor antagonism with serotonin reuptake inhibition only occur at moderate to high doses of trazodone. [74] Doses of trazodone lower than those effective for antidepressant action are frequently used for the effective treatment of insomnia. [74] Low doses exploit trazodone’s potent actions as a 5-HT2A receptor antagonist, and its properties as an antagonist of H1 and α1-adrenergic receptors, but do not adequately exploit its SERT or 5-HT2C inhibition properties, which are weaker. [74] Since insomnia is one of the most frequent residual symptoms of depression after treatment with an SSRI, a hypnotic is often necessary for patients with a major depressive episode. [74] Not only can a hypnotic potentially relieve the insomnia itself, but treating insomnia in patients with major depression may also increase remission rates due to improvement of other symptoms such as loss of energy and depressed mood. [74] Thus, the ability of low doses of trazodone to improve sleep in depressed patients may be an important mechanism whereby trazodone can augment the efficacy of other antidepressants. [74]

Trazodone’s potent α1-adrenergic blockade may cause some side effects like orthostatic hypotension and sedation . [75] Conversely, along with 5-HT2A and H1 receptor antagonism, it may contribute to its efficacy as a hypnotic . Trazodone lacks any affinity for the muscarinic acetylcholine receptors , so does not produce anticholinergic side effects.

mCPP , a non-selective serotonin receptor modulator and serotonin releasing agent , is the major active metabolite of trazodone and has been suggested to possibly play a role in its therapeutic benefits. [76] [77] [78] However, scientific research has not supported this hypothesis, and mCPP may actually antagonize trazodone’s efficacy as well as produce additional side effects. [79] [80] [81] [82] [83]

Pharmacokinetics[ edit ]

Trazodone is well absorbed after oral administration , with mean peak blood levels obtained at about one hour after ingestion. Absorption is somewhat delayed and enhanced by food. The drug is highly protein-bound . Trazodone is extensively metabolized , with three or four major metabolites having been identified in the human body, particularly mCPP , [45] which may contribute to the side effect profile of trazodone and which probably accounts for trazodone’s serotonergic effects. [84] Levels of trazodone are about 10-fold those of mCPP with treatment. [85] The mean blood elimination half-life of trazodone is biphasic: the first phase’s half-life is 3 to 6 hours, and the following phase’s half-life is 5 to 9 hours. Around 70 to 75% of 14C-labelled trazodone was found to be excreted in the urine within 72 hours. [86]

As a consequence of the production of mCPP as a metabolite, patients administered trazodone may test positive on EMIT II urine tests for the presence of MDMA (“ecstasy”). [87]

Chemistry[ edit ]

Trazodone is a triazolopyridine derivative and a phenylpiperazine that is chemically related to nefazodone and etoperidone , each of which are derivatives of it. [88] [89] [90]

History[ edit ]

Trazodone was developed in Italy , in the 1960s, by Angelini Research Laboratories as a second-generation antidepressant . [91] [92] It was developed according to the mental pain hypothesis, which was postulated from studying patients and which proposes that major depression is associated with a decreased pain threshold. [93] In sharp contrast to most other antidepressants available at the time of its development, trazodone showed minimal effects on muscarinic cholinergic receptors. Trazodone was patented and marketed in many countries all over the world. It was approved by the Food and Drug Administration (FDA) in 1981 [94] and was the first non- tricyclic antidepressant approved in the US. [95]

Society and culture[ edit ]

Generic names[ edit ]

Trazodone is the generic name of the drug and its INN , BAN , and DCF , while trazodone hydrochloride is its USAN , USP , BANM , and JAN . [96] [97] [98] [99]

Brand names[ edit ]

Trazodone has been marketed under a large number of brand names throughout the world. [97] [99] Major brand names include Desyrel (worldwide), Molipaxin ( IE , UK ), Oleptro ( US ), Trazorel ( CA ), and Trittico (worldwide). [97] [99]

References[ edit ]

  1. ^ a b Drugs.com international listings for Trazodone Page accessed Feb 10, 2016
  2. ^ Lemke, Thomas L.; Williams, David A. (2012). Foye’s Principles of Medicinal Chemistry . Lippincott Williams & Wilkins. p. 615. ISBN   9781609133450 .

  3. ^ a b c d e Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013.[ not in citation given ]
  4. ^ “Trazodone” . DrugBank. Retrieved 7 June 2015.
  5. ^ Sheldon H. Preskorn; Christina Y. Stanga; John P. Feighner; Ruth Ross (6 December 2012). Antidepressants: Past, Present and Future . Springer Science & Business Media. pp. 68–. ISBN   978-3-642-18500-7 .
  6. ^ “MicroMedex DrugPoints – Trazodone” . Pharmacy Choice. Retrieved 20 April 2017.
  7. ^ Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. (2017). The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition . American Psychiatric Pub. pp. 460–. ISBN   978-1-58562-523-9 .CS1 maint: Multiple names: authors list ( link )
  8. ^ a b c d e f g “Trazodone Hydrochloride” . The American Society of Health-System Pharmacists. Retrieved 8 January 2018.
  9. ^ “Trazodone Use During Pregnancy” . Drugs.com. Retrieved 7 January 2018.
  10. ^ Stahl, Stephen M. (2008). Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications . Cambridge University Press. p. 567. ISBN   9780521857024 .
  11. ^ Lemke, Thomas L.; Williams, David A. (2008). Foye’s Principles of Medicinal Chemistry . Lippincott Williams & Wilkins. p. 586. ISBN   9780781768795 .
  12. ^ a b British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 257–258. ISBN   9780857111562 .
  13. ^ “NADAC as of 2018-01-03” . Centers for Medicare and Medicaid Services. Retrieved 7 January 2018.
  14. ^ “Trazodone hydrochloride prescriptions number U.S. 2004-2014” . Statista. Retrieved 7 January 2018.
  15. ^ “Desyrel – FDA Prescribing Information” . Drugs.com. Retrieved 4 June 2015.
  16. ^ British National Formulary (BNF) 65. London, UK: Pharmaceutical Press. 2013. p. 247. ISBN   9780857110848 .
  17. ^ Nierenberg AA, Adler LA, Peselow E, Zornberg G, Rosenthal M (July 1994). “Trazodone for antidepressant-associated insomnia” . Am J Psychiatry. 151 (7): 1069–72. doi : 10.1176/ajp.151.7.1069 . PMID   8010365 .
  18. ^ a b c d Schatzberg, AF; Nemeroff, CB, eds. (2009). Textbook of Psychopharmacology (4th ed.). Washington, D.C.: American Psychiatric Publishing. ISBN   978-1-58562-309-9 .
  19. ^ “Understanding the Pharmacologic Therapy for Complex Regional Pain Syndrome: Pharmacologic Therapy” . Medscape.com. Retrieved 2014-03-14.
  20. ^ Prasad A (February 1985). “Efficacy of trazodone as an anti obsessional agent” . Pharmacol. Biochem. Behav. 22 (2): 347–8. doi : 10.1016/0091-3057(85)90403-4 . PMID   3983224 .
  21. ^ Roccatagliata G; Albano C; Maffini M; Farelli S (1980). “Alcohol withdrawal syndrome: treatment with trazodone”. Int Pharmacopsychiatry. 15 (2): 105–10. doi : 10.1159/000468420 . PMID   6108298 .
  22. ^ Le Bon O; Murphy JR; Staner L; Hoffmann G; Kormoss N; Kentos M; Dupont P; Lion K; Pelc I; Verbanck P (August 2003). “Double-blind, placebo-controlled study of the efficacy of trazodone in alcohol post-withdrawal syndrome: polysomnographic and clinical evaluations”. J Clin Psychopharmacol. 23 (4): 377–83. doi : 10.1097/01.jcp.0000085411.08426.d3 . PMID   12920414 .
  23. ^ Borras L; de Timary P; Constant EL; Huguelet P; Eytan A (November 2006). “Successful treatment of alcohol withdrawal with trazodone”. Pharmacopsychiatry. 39 (6): 232. doi : 10.1055/s-2006-951385 . PMID   17124647 .
  24. ^ Singh, SP; Singh, V; Kar, N; Chan, K (2010). “Efficacy of antidepressants in treating the negative symptoms of chronic schizophrenia: meta-analysis” (PDF). The British Journal of Psychiatry. 197 (3): 174–179. doi : 10.1192/bjp.bp.109.067710 . PMID   20807960 .
  25. ^ Fink, HA; MacDonald, R; Rutks, IR; Wilt, TJ (September 2003). “Trazodone for erectile dysfunction: a systematic review and meta-analysis”. BJU International. 92 (4): 441–446. doi : 10.1046/j.1464-410X.2003.04358.x . PMID   12930437 .
  26. ^ “Trazodone – FDA prescribing information, side effects and uses” .
  27. ^ “Desyrel (Trazodone Hydrochloride): Side Effects, Interactions, Warning, Dosage & Uses” .
  28. ^ “Webmd.com” . Webmd.com. Retrieved 2014-03-14.
  29. ^ Warner CH, Bobo W, Warner C, Reid S, Rachal J; Bobo; Warner; Reid; Rachal (August 2006). “Antidepressant discontinuation syndrome” . Am Fam Physician. 74 (3): 449–56. PMID   16913164 .CS1 maint: Multiple names: authors list ( link )
  30. ^ Einarson, A; Bonari, L; Voyer-Lavigne, S; Addis, A; Matsui, D; Johnson, Y; Koren, G (March 2003). “A multicentre prospective controlled study to determine the safety of trazodone and nefazodone use during pregnancy”. Can J Psychiatry. 48 (2): 106–110. doi : 10.1177/070674370304800207 . PMID   12655908 .
  31. ^ Verbeeck, RK; Ross, SG; McKenna, EA (September 1986). “Excretion of trazodone in breast milk” . Br J Clin Pharmacol. 22 (3): 367–370. doi : 10.1111/j.1365-2125.1986.tb02903.x . PMC   1401139 . PMID   3768252 .
  32. ^ Wesnes, KA; Simpson, PM; Christmas, L; Anand, R; McClelland, GR (1989). “The effects of moclobemide on cognition”. J. Neural Transm. Suppl. 28: 91–102. PMID   2677245 .
  33. ^ a b Schatzberg, AF; Nemeroff, CB, eds. (2009). Textbook of Psychopharmacology (4th ed.). Washington, D.C.: American Psychiatric Publishing. ISBN   978-1-58562-309-9 .
  34. ^ “Trazodone PRODUCT MONOGRAPH” (PDF). 2015.
  35. ^ “HIGHLIGHTS OF PRESCRIBING INFORMATION” (PDF). U.S. Food and Drug Administration. 2017.
  36. ^ Abber, RE;; et al. (1987). “Priapism induced by chlorpromazine and trazodone: mechanism of action”. J. Urol. 137 (5): 1039–1042. doi : 10.1016/s0022-5347(17)44355-2 . PMID   3573170 .CS1 maint: Multiple names: authors list ( link )
  37. ^ Battaglia; ven Turoli RE (2009). “Persistent genital arousal disorder and trazodone. 5555Morphometric and vascular modifications of the clitoris. A case report”. J Sex Med . 6 (10): 2896–2900. doi : 10.1111/j.1743-6109.2009.01418.x . PMID   19674253 .
  38. ^ Kalgutkar AS, Henne KR, Lame ME; Henne; Lame; Vaz; Collin; Soglia; Zhao; Hop (June 2005). “Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4” . Chem Biol Interact. 155 (1–2): 10–20. doi : 10.1016/j.cbi.2005.03.036 . PMID   15978881 .CS1 maint: Multiple names: authors list ( link )
  39. ^ Otani K, Yasui N, Kaneko S; Yasui; Kaneko; Ishida; Ohkubo; Osanai; Sugawara; Fukushima (June 1995). “Trazodone treatment increases plasma prolactin concentrations in depressed patients”. Int Clin Psychopharmacol. 10 (2): 115–7. doi : 10.1097/00004850-199506000-00009 . PMID   7673654 .CS1 maint: Multiple names: authors list ( link )
  40. ^ “Selective Serotonin Reuptake Inhibitor Toxicity” . 2014-02-26.
  41. ^ “Selective Serotonin Reuptake Inhibitor Toxicity” . 2014-02-26.
  42. ^ Martínez MA, Ballesteros S, Sánchez de la Torre C, Almarza E; Ballesteros; Sánchez de la Torre C; Almarza (2005). “Investigation of a fatality due to trazodone poisoning: case report and literature review” . J Anal Toxicol. 29 (4): 262–8. doi : 10.1093/jat/29.4.262 . PMID   15975258 . Archived from the original on 2012-07-11.CS1 maint: Multiple names: authors list ( link )
  43. ^ de Meester A, Carbutti G, Gabriel L, Jacques JM; Carbutti; Gabriel; Jacques (2001). “Fatal overdose with trazodone: case report and literature review”. Acta Clin Belg. 56 (4): 258–61. doi : 10.1179/acb.2001.038 . PMID   11603256 .CS1 maint: Multiple names: authors list ( link )
  44. ^ Rakel RE (1987). “The greater safety of trazodone over tricyclic antidepressant agents: 5-year experience in the United States”. Psychopathology. 20 (Suppl 1): 57–63. doi : 10.1159/000284524 . PMID   3321131 .
  45. ^ a b Rotzinger S, Fang J, Baker GB; Fang; Baker (1 June 1998). “Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources” . Drug Metab. Dispos. 26 (6): 572–5. PMID   9616194 .CS1 maint: Multiple names: authors list ( link )
  46. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an Roth, BL; Driscol, J. “PDSP Ki Database” . Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Retrieved 14 August 2017.
  47. ^ Roth, BL; Driscol, J. “PDSP Ki Database”. Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Retrieved 25 May 2018.
  48. ^ a b c d Owens MJ, Morgan WN, Plott SJ, Nemeroff CB (1997). “Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites”. J. Pharmacol. Exp. Ther. 283 (3): 1305–22. PMID   9400006 .
  49. ^ a b c Tatsumi M, Groshan K, Blakely RD, Richelson E (1997). “Pharmacological profile of antidepressants and related compounds at human monoamine transporters”. Eur. J. Pharmacol. 340 (2–3): 249–58. doi : 10.1016/s0014-2999(97)01393-9 . PMID   9537821 .
  50. ^ a b c d e f g Cusack B, Nelson A, Richelson E (1994). “Binding of antidepressants to human brain receptors: focus on newer generation compounds”. Psychopharmacology. 114 (4): 559–65. doi : 10.1007/bf02244985 . PMID   7855217 .
  51. ^ a b c d e f g h i j Hamik A, Peroutka SJ (1989). “1-(m-chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain”. Biol. Psychiatry. 25 (5): 569–75. doi : 10.1016/0006-3223(89)90217-5 . PMID   2537663 .
  52. ^ Boess FG, Martin IL (1994). “Molecular biology of 5-HT receptors”. Neuropharmacology. 33 (3–4): 275–317. doi : 10.1016/0028-3908(94)90059-0 . PMID   7984267 .
  53. ^ Hamblin MW, Metcalf MA (1991). “Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor”. Mol. Pharmacol. 40 (2): 143–8. PMID   1652050 .
  54. ^ a b c Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (2004). “Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors”. Naunyn Schmiedebergs Arch. Pharmacol. 370 (2): 114–23. doi : 10.1007/s00210-004-0951-4 . PMID   15322733 .
  55. ^ Bonhaus DW, Bach C, DeSouza A, Salazar FH, Matsuoka BD, Zuppan P, Chan HW, Eglen RM (1995). “The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors” . Br. J. Pharmacol. 115 (4): 622–8. doi : 10.1111/j.1476-5381.1995.tb14977.x . PMC   1908489 . PMID   7582481 .
  56. ^ a b Rothman RB, Baumann MH (2009). “Serotonergic drugs and valvular heart disease” . Expert Opin Drug Saf. 8 (3): 317–29. doi : 10.1517/14740330902931524 . PMC   2695569 . PMID   19505264 .
  57. ^ Rothman RB, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ, Roth BL (2000). “Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications”. Circulation. 102 (23): 2836–41. doi : 10.1161/01.cir.102.23.2836 . PMID   11104741 .
  58. ^ Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ (1999). “Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells” . Br. J. Pharmacol. 128 (1): 13–20. doi : 10.1038/sj.bjp.0702751 . PMC   1571597 . PMID   10498829 .
  59. ^ Bentley JM, Adams DR, Bebbington D, Benwell KR, Bickerdike MJ, Davidson JE, Dawson CE, Dourish CT, Duncton MA, Gaur S, George AR, Giles PR, Hamlyn RJ, Kennett GA, Knight AR, Malcolm CS, Mansell HL, Misra A, Monck NJ, Pratt RM, Quirk K, Roffey JR, Vickers SP, Cliffe IA (2004). “Indoline derivatives as 5-HT(2C) receptor agonists”. Bioorg. Med. Chem. Lett. 14 (9): 2367–70. doi : 10.1016/j.bmcl.2003.05.001 . PMID   15081042 .
  60. ^ Bonhaus DW, Weinhardt KK, Taylor M, DeSouza A, McNeeley PM, Szczepanski K, Fontana DJ, Trinh J, Rocha CL, Dawson MW, Flippin LA, Eglen RM (1997). “RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist”. Neuropharmacology. 36 (4–5): 621–9. doi : 10.1016/s0028-3908(97)00049-x . PMID   9225287 .
  61. ^ a b c d Richelson E, Nelson A (1984). “Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro”. J. Pharmacol. Exp. Ther. 230 (1): 94–102. PMID   6086881 .
  62. ^ a b Stanton T, Bolden-Watson C, Cusack B, Richelson E (1993). “Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics”. Biochem. Pharmacol. 45 (11): 2352–4. doi : 10.1016/0006-2952(93)90211-e . PMID   8100134 .
  63. ^ Fagiolini A, Comandini A, Catena Dell’Osso M, Kasper S (2012). “Rediscovering trazodone for the treatment of major depressive disorder” . CNS Drugs. 26 (12): 1033–49. doi : 10.1007/s40263-012-0010-5 . PMC   3693429 . PMID   23192413 .
  64. ^ Khouzam HR (2017). “A review of trazodone use in psychiatric and medical conditions”. Postgrad Med. 129 (1): 140–148. doi : 10.1080/00325481.2017.1249265 . PMID   27744763 .
  65. ^ Thomas L. Lemke; David A. Williams (2008). Foye’s Principles of Medicinal Chemistry . Lippincott Williams & Wilkins. pp. 586–. ISBN   978-0-7817-6879-5 .
  66. ^ a b Raffa RB, Shank RP, Vaught JL; Shank; Vaught (1992). “Etoperidone, trazodone and MCPP: in vitro and in vivo identification of serotonin 5-HT1A (antagonistic) activity”. Psychopharmacology. 108 (3): 320–6. doi : 10.1007/BF02245118 . PMID   1387963 .CS1 maint: Multiple names: authors list ( link )
  67. ^ a b Odagaki Y, Toyoshima R, Yamauchi T; Toyoshima; Yamauchi (May 2005). “Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding” . Journal of Psychopharmacology (Oxford, England). 19 (3): 235–41. doi : 10.1177/0269881105051526 . PMID   15888508 .CS1 maint: Multiple names: authors list ( link )
  68. ^ Kahn RS, Wetzler S (1991). “m-Chlorophenylpiperazine as a probe of serotonin function”. Biol. Psychiatry. 30 (11): 1139–66. doi : 10.1016/0006-3223(91)90184-n . PMID   1663792 .
  69. ^ Krystal AD, Richelson E, Roth T (2013). “Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications”. Sleep Med Rev. 17 (4): 263–72. doi : 10.1016/j.smrv.2012.08.001 . PMID   23357028 .
  70. ^ a b c Marek GJ, McDougle CJ, Price LH, Seiden LS; McDougle; Price; Seiden (1992). “A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action”. Psychopharmacology. 109 (1–2): 2–11. doi : 10.1007/BF02245475 . PMID   1365657 .CS1 maint: Multiple names: authors list ( link )
  71. ^ Vanina Y, Podolskaya A, Sedky K, et al. (July 2002). “Body weight changes associated with psychopharmacology” . Psychiatric Services. 53 (7): 842–7. doi : 10.1176/appi.ps.53.7.842 . PMID   12096167 .
  72. ^ Watanabe N, Omori IM, Nakagawa A, et al. (January 2010). “Safety reporting and adverse-event profile of mirtazapine described in randomized controlled trials in comparison with other classes of antidepressants in the acute-phase treatment of adults with depression: systematic review and meta-analysis” . CNS Drugs. 24 (1): 35–53. doi : 10.2165/11319480-000000000-00000 . PMID   20030418 .
  73. ^ Kinney GG, Griffith JC, Hudzik TJ; Griffith; Hudzik (July 1998). “Antidepressant-like effects of 5-hydroxytryptamine1A receptor agonists on operant responding under a response duration differentiation schedule”. Behavioural Pharmacology. 9 (4): 309–18. doi : 10.1097/00008877-199807000-00002 . PMID   10065919 .CS1 maint: Multiple names: authors list ( link )
  74. ^ a b c d e f Stahl, S.M. (2013). Stahl’s Essential Psychopharmacology (4th ed.). Cambridge University Press. ISBN   978-1107686465 .
  75. ^ Asayesh K (December 1986). “Combination of trazodone and phenothiazines: a possible additive hypotensive effect”. Canadian Journal of Psychiatry. 31 (9): 857–8. PMID   3802006 .
  76. ^ Melzacka M, Rurak, Vetulani (1980). “Preliminary study of the biotransformation of two new drugs, trazodone and etoperidone”. Polish Journal of Pharmacology and Pharmacy. 32 (4): 551–6. PMID   7255270 .
  77. ^ Fong MH, Garattini S, Caccia S; Garattini; Caccia (October 1982). “1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole”. The Journal of Pharmacy and Pharmacology. 34 (10): 674–75. doi : 10.1111/j.2042-7158.1982.tb04701.x . PMID   6128394 .CS1 maint: Multiple names: authors list ( link )
  78. ^ Maes M, Westenberg H, Vandoolaeghe E, et al. (October 1997). “Effects of trazodone and fluoxetine in the treatment of major depression: therapeutic pharmacokinetic and pharmacodynamic interactions through formation of meta-chlorophenylpiperazine” . Journal of Clinical Psychopharmacology. 17 (5): 358–64. doi : 10.1097/00004714-199710000-00004 . PMID   9315986 .
  79. ^ Mihara K, Yasui-Furukori N, Kondo T, et al. (August 2002). “Relationship between plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, and its clinical effect in depressed patients” . Therapeutic Drug Monitoring. 24 (4): 563–6. doi : 10.1097/00007691-200208000-00016 . PMID   12142643 .
  80. ^ Li AA, Marek GJ, Hand TH, Seiden LS; Marek; Hand; Seiden (February 1990). “Antidepressant-like effects of trazodone on a behavioral screen are mediated by trazodone, not the metabolite m-chlorophenylpiperazine”. European Journal of Pharmacology. 177 (3): 137–144. doi : 10.1016/0014-2999(90)90263-6 . PMID   2311675 .CS1 maint: Multiple names: authors list ( link )
  81. ^ Vetulani J, Sansone M, Baran L, Hano J; Sansone; Baran; Hano (1984). “Opposite action of m-chlorophenylpiperazine on avoidance depression induced by trazodone and pimozide in CD-1 mice”. Psychopharmacology. 83 (2): 166–8. doi : 10.1007/BF00429728 . PMID   6431467 .CS1 maint: Multiple names: authors list ( link )
  82. ^ Kast RE (2009). “Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone”. World Journal of Biological Psychiatry. 10 (4 Pt 2): 682–5. doi : 10.1080/15622970902836022 . PMID   19384678 .
  83. ^ Workman EA, Tellian F, Short D; Tellian; Short (May 1992). “Trazodone induction of migraine headache through mCPP”. The American Journal of Psychiatry. 149 (5): 712. doi : 10.1176/ajp.149.5.712b . PMID   1575270 .CS1 maint: Multiple names: authors list ( link )
  84. ^ Garattini, S (1985). “Active drug metabolites. An overview of their relevance in clinical pharmacokinetics”. Clinical Pharmacokinetics. 10 (3): 216–27. doi : 10.2165/00003088-198510030-00002 . PMID   2861928 .
  85. ^ Roy J. Vaz; Thomas Klabunde (9 April 2008). Antitargets: Prediction and Prevention of Drug Side Effects . John Wiley & Sons. pp. 149–. ISBN   978-3-527-62147-7 .
  86. ^ Jauch R, Kopitar Z, Prox A, Zimmer A; Kopitar; Prox; Zimmer (1976). “[Pharmacokinetics and metabolism of trazodone in man (author’s transl)]” [Pharmacokinetics and metabolism of trazodone in man (author’s transl)]. Arzneimittelforschung (in German). 26 (11): 2084–9. PMID   1037253 .CS1 maint: Multiple names: authors list ( link )
  87. ^ Logan BK, Costantino AG, Rieders EF, Sanders D; Costantino; Rieders; Sanders (Nov 2010). “Trazodone, meta-chlorophenylpiperazine (a hallucinogenic drug and trazodone metabolite), and the hallucinogen trifluoromethylphenylpiperazine cross-react with the EMIT®II ecstasy immunoassay in urine”. J Anal Toxicol. 34 (9): 587–9. doi : 10.1093/jat/34.9.587 . PMID   21073812 .CS1 maint: Multiple names: authors list ( link )
  88. ^ Akritopoulou-Zanze, Irini (2012). “6. Arylpiperazine-Based 5-HT1A Receptor Partial Agonists and 5-HT2A Antagonists for the Treatment of Autism, Depression, Anxiety, Psychosis, and Schizophrenia”. In Dinges, Jürgen; Lamberth, Clemens. Bioactive heterocyclic compound classes pharmaceuticals. Weinheim: Wiley-VCH. ISBN   9783527664450 .
  89. ^ Dörwald, Florencioa Zaragoza, ed. (2012). “46. Arylalkylamines”. Lead optimization for medicinal chemists : pharmacokinetic properties of functional groups and organic compounds. Weinheim: Wiley-VCH. ISBN   9783527645640 .
  90. ^ Haria, M; Fitton, A; McTavish, D (April 1994). “Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders”. Drugs & Aging. 4 (4): 331–55. doi : 10.2165/00002512-199404040-00006 . PMID   8019056 .
  91. ^ Gorecki, Dennis K.J.; Verbeeck, Roger K. (1987). “Trazondone Hydrochloride” . In Forey, Klaus. Profiles of Drug Substances, Excipients and Related Methodology Vol. 16. Academic Press. p. 695. ISBN   9780080861111 .
  92. ^ Wegener, Gregers (30 March 2016). “Ban & Silvestrini’s Trazodone” . inhn.org. Retrieved 4 June 2017.
  93. ^ Silvestrini B (1989). “Trazodone: from the mental pain to the “dys-stress” hypothesis of depression”. Clin Neuropharmacol. 12 (Suppl 1): S4–10. doi : 10.1097/00002826-198901001-00002 . PMID   2568177 .
  94. ^ “Trazodone: Common sleep drug is little-known antidepressant – Consumer Reports” . Consumer Reports. August 2015.
  95. ^ Eisen, Michael S.; Taylor, Duncan B.; Riblet, Leslie A. (2012). “Atypical Psychotropic Agents” . In Williams, Michael; Malick, Jeffrey B. Drug Discovery and Development. Springer Science & Business Media. p. 388. ISBN   9781461248286 .
  96. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer. ISBN   978-1-4757-2085-3 .
  97. ^ a b c Index Nominum 2000: International Drug Directory . Taylor & Francis. 2000. pp. 1050–1052. ISBN   978-3-88763-075-1 .
  98. ^ I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms . Springer Science & Business Media. pp. 279–. ISBN   978-94-011-4439-1 .
  99. ^ a b c “Trazodone” .

External links[ edit ]

  • U.S. National Library of Medicine: Drug Information Portal – Trazodone
Medical uses
  • v
  • t
  • e
Antidepressants ( N06A )
Specific reuptake inhibitors and/or receptor modulators
SSRIs
  • Citalopram
  • Escitalopram
  • Fluoxetine #
  • Fluvoxamine
  • Indalpine
  • Paroxetine
  • Sertraline
  • Zimelidine
SNRIs
  • Desvenlafaxine
  • Duloxetine
  • Levomilnacipran
  • Milnacipran
  • Tofenacin
  • Venlafaxine
NRIs
  • Atomoxetine
  • Reboxetine
  • Viloxazine
NDRIs
  • Amineptine
  • Bupropion
  • Nomifensine
NaSSAs
  • Mianserin
  • Mirtazapine
  • Setiptiline
SARIs
  • Etoperidone
  • Nefazodone
  • Trazodone
SMS
  • Vilazodone
  • Vortioxetine
Others
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  • Tianeptine
Tricyclic and tetracyclic antidepressants
TCAs
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  • Amitriptyline #
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  • Butriptyline
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MAOB -selective
  • Irreversible: Selegiline
Adjunctive therapies
  • Atypical antipsychotics ( aripiprazole , brexpiprazole , lurasidone , olanzapine , quetiapine , risperidone )
  • Buspirone
  • Lithium ( lithium carbonate , lithium citrate )
  • Thyroid hormones ( triiodothyronine (T3), levothyroxine (T4))
Miscellaneous
  • Ademetionine ( SAMe)
  • Hypericum perforatum (St. John’s Wort)
  • Oxitriptan ( 5-HTP)
  • Rubidium chloride (RbCl)
  • Tryptophan
  • # WHO-EM
  • Withdrawn from market
  • Clinical trials :
    • Phase III
    • §Never to phase III
  • v
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  • e
Anxiolytics ( N05B )
5-HT1AR agonists
  • Buspirone
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  • Tandospirone
GABAAR PAMs
  • Benzodiazepines : Adinazolam
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  • Prazepam ; Others: Alpidem
  • Barbiturates (e.g., phenobarbital )
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  • Ethanol (alcohol)
  • Etifoxine
  • Imepitoin ; Herbs:
  • Kava
  • Skullcap
  • Valerian
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( α2δ VDCC blockers )
  • Gabapentin
  • Gabapentin enacarbil
  • Phenibut
  • Pregabalin
Antidepressants
  • SSRIs (e.g., escitalopram )
  • SNRIs (e.g., duloxetine )
  • SARIs (e.g., trazodone )
  • TCAs (e.g., clomipramine #)
  • TeCAs (e.g., mirtazapine )
  • MAOIs (e.g., phenelzine ); Others: Agomelatine
  • Bupropion
  • Tianeptine
  • Vilazodone
  • Vortioxetine
Sympatholytics
( Antiadrenergics )
  • Alpha-1 blockers (e.g., prazosin )
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  • Beta blockers (e.g., propranolol )
Others
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  • Oxaflozane
  • Phenaglycodol
  • Phenibut
  • Picamilon
  • Selank
  • Tiagabine
  • Tofisopam
  • Validolum
  • # WHO-EM
  • Withdrawn from market
  • Clinical trials :
    • Phase III
    • §Never to phase III
  • v
  • t
  • e
Hypnotics / sedatives ( N05C )
GABAA
Alcohols
  • 2M2B
  • Chloralodol
  • Ethanol (alcohol)
  • Ethchlorvynol
  • Methylpentynol
  • Trichloroethanol
Barbiturates
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  • Pentobarbital
  • Phenallymal
  • Phenobarbital
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  • Proxibarbal
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  • Vinbarbital
  • Vinylbital
Benzodiazepines
  • Brotizolam
  • Cinolazepam
  • Climazolam
  • Doxefazepam
  • Estazolam
  • Flunitrazepam
  • Flurazepam
  • Flutoprazepam
  • Lorazepam
  • Loprazolam
  • Lormetazepam
  • Midazolam
  • Nimetazepam
  • Nitrazepam
  • Phenazepam
  • Quazepam
  • Temazepam
  • Triazolam
Carbamates
  • Carisoprodol
  • Emylcamate
  • Ethinamate
  • Hexapropymate
  • Meprobamate
  • Methocarbamol
  • Phenprobamate
  • Procymate
  • Tybamate
Imidazoles
  • Etomidate
  • Metomidate
  • Propoxate
Monoureides
  • Acecarbromal
  • Apronal (apronalide)
  • Bromisoval
  • Capuride
  • Carbromal
  • Ectylurea
Neuroactive steroids
  • Acebrochol
  • Allopregnanolone
  • Alphadolone
  • Alphaxolone
  • Eltanolone
  • Hydroxydione
  • Minaxolone
  • Progesterone
Nonbenzodiazepines
  • Eszopiclone
  • Indiplon
  • Lirequinil
  • Necopidem
  • Pazinaclone
  • Saripidem
  • Suproclone
  • Suriclone
  • Zaleplon
  • Zolpidem
  • Zopiclone
Phenols
  • Propofol
Piperidinediones
  • Glutethimide
  • Methyprylon
  • Pyrithyldione
  • Piperidione
Quinazolinones
  • Afloqualone
  • Cloroqualone
  • Diproqualone
  • Etaqualone
  • Mebroqualone
  • Mecloqualone
  • Methaqualone
  • Methylmethaqualone
  • Nitromethaqualone
Others
  • Acetophenone
  • Acetylglycinamide chloral hydrate
  • Bromide compounds
    • Lithium bromide
    • Potassium bromide
    • Sodium bromide
  • Centalun
  • Chloral betaine
  • Chloral hydrate
  • Chloralose
  • Clomethiazole
  • Dichloralphenazone
  • Gaboxadol
  • Kavalactones
  • Loreclezole
  • Paraldehyde
  • Petrichloral
  • Sulfonylalkanes
    • Sulfonmethane (sulfonal)
    • Tetronal
    • Trional
  • Triclofos
  • Sesquiterpene
    • Isovaleramide
    • Isovaleric acid
    • Valerenic acid
GABAB
  • 1,4-Butanediol
  • 4-Fluorophenibut
  • Aceburic acid
  • Baclofen
  • GABOB
  • GHB ( sodium oxybate )
  • GBL
  • GVL
  • Phenibut
  • Tolibut
H1
Antihistamines
  • Captodiame
  • Cyproheptadine
  • Diphenhydramine
  • Doxylamine
  • Hydroxyzine
  • Methapyrilene
  • Perlapine
  • Pheniramine
  • Promethazine
  • Propiomazine
Antidepressants
  • Serotonin antagonists and reuptake inhibitors
    • Etoperidone
    • Nefazodone
    • Trazodone
  • Tricyclic antidepressants
    • Amitriptyline
    • Doxepin
    • Trimipramine , etc.
  • Tetracyclic antidepressants
    • Mianserin
    • Mirtazapine , etc.
Antipsychotics
  • Typical antipsychotics
    • Chlorpromazine
    • Thioridazine , etc.
  • Atypical antipsychotics
    • Olanzapine
    • Quetiapine
    • Risperidone , etc.
α2-Adrenergic
  • Clonidine
  • Detomidine
  • Dexmedetomidine
  • Lofexidine
  • Medetomidine
  • Romifidine
  • Tizanidine
  • Xylazine
5-HT2A
Antidepressants
  • Trazodone
  • Tricyclic antidepressants
    • Amitriptyline
    • Doxepin
    • Trimipramine , etc.
  • Tetracyclic antidepressants
    • Mianserin
    • Mirtazapine , etc.
Antipsychotics
  • Typical antipsychotics
    • Chlorpromazine
    • Thioridazine , etc.
  • Atypical antipsychotics
    • Olanzapine
    • Quetiapine
    • Risperidone , etc.
Others
  • Niaprazine
Melatonin
  • Agomelatine
  • Melatonin
  • Ramelteon
  • Tasimelteon
Orexin
  • Almorexant
  • Filorexant
  • Suvorexant
α2δ VDCC
  • Gabapentin
  • Gabapentin enacarbil
  • Mirogabalin
  • Phenibut
  • Pregabalin
Others
  • Cannabidiol
    • Cannabis
  • Chlorophenylalkyldiols
    • Fenpentadiol
    • Metaglycodol
    • Phenaglycodol
  • Diethylpropanediol
  • Evoxine
  • Fenadiazole
  • Guaifenesin -related muscle relaxants
    • Chlorphenesin
    • Mephenesin
    • Mephenoxalone
    • Metaxalone
    • Methocarbamol
  • Opioids (e.g., morphine )
  • Passion flower
  • Scopolamine
  • Trazodone
  • UMB68
  • Valnoctamide
Pharmacodynamics
  • v
  • t
  • e
Adrenergic receptor modulators
α1
  • Agonists: 6-FNE
  • Amidephrine
  • Anisodine
  • Buspirone
  • Cirazoline
  • Corbadrine
  • Desglymidodrine
  • Dexisometheptene
  • Dipivefrine
  • Dopamine
  • Droxidopa (L-DOPS)
  • Ephedrine
  • Epinephrine
  • Etilefrine
  • Etilevodopa
  • Ethylnorepinephrine
  • Indanidine
  • Isometheptene
  • L-DOPA (levodopa)
  • L-Phenylalanine
  • L-Tyrosine
  • Melevodopa
  • Metaraminol
  • Methoxamine
  • Methyldopa
  • Midodrine
  • Naphazoline
  • Norepinephrine
  • Octopamine (drug)
  • Oxymetazoline
  • Phenylephrine
  • Phenylpropanolamine
  • Pseudoephedrine
  • Synephrine
  • Tetryzoline
  • Tiamenidine
  • XP21279
  • Xylometazoline
  • Antagonists: Abanoquil
  • Adimolol
  • Ajmalicine
  • Alfuzosin
  • Amosulalol
  • Anisodamine
  • Arotinolol
  • Atiprosin
  • Atypical antipsychotics (e.g., brexpiprazole , clozapine , olanzapine , quetiapine , risperidone )
  • Benoxathian
  • Buflomedil
  • Bunazosin
  • Carvedilol
  • Corynanthine
  • Dapiprazole
  • Domesticine
  • Doxazosin
  • Ergolines (e.g., ergotamine , dihydroergotamine , lisuride , terguride )
  • Etoperidone
  • Eugenodilol
  • Fenspiride
  • Hydroxyzine
  • Indoramin
  • Ketanserin
  • L-765,314
  • Labetalol
  • mCPP
  • Mepiprazole
  • Metazosin
  • Monatepil
  • Moxisylyte
  • Naftopidil
  • Nantenine
  • Neldazosin
  • Niaprazine
  • Nicergoline
  • Niguldipine
  • Pardoprunox
  • Pelanserin
  • Perlapine
  • Phendioxan
  • Phenoxybenzamine
  • Phentolamine
  • Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )
  • Piperoxan
  • Prazosin
  • Quinazosin
  • Quinidine
  • Ritanserin
  • Silodosin
  • Spiperone
  • Talipexole
  • Tamsulosin
  • Terazosin
  • Tiodazosin
  • Tolazoline
  • Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin )
  • Tricyclic antidepressants (e.g., amitriptyline , clomipramine , doxepin , imipramine , trimipramine )
  • Trimazosin
  • Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )
  • Urapidil
  • WB-4101
  • Zolertine
α2
  • Agonists: (R)-3-Nitrobiphenyline
  • 4-NEMD
  • 6-FNE
  • Amitraz
  • Apraclonidine
  • Brimonidine
  • Cannabivarin
  • Clonidine
  • Corbadrine
  • Detomidine
  • Dexmedetomidine
  • Dihydroergotamine
  • Dipivefrine
  • Dopamine
  • Droxidopa (L-DOPS)
  • Etilevodopa
  • Ephedrine
  • Ergotamine
  • Epinephrine
  • Etilefrine
  • Ethylnorepinephrine
  • Guanabenz
  • Guanfacine
  • Guanoxabenz
  • L-DOPA (levodopa)
  • L-Phenylalanine
  • L-Tyrosine
  • Lofexidine
  • Medetomidine
  • Melevodopa
  • Methyldopa
  • Mivazerol
  • Naphazoline
  • Norepinephrine
  • Oxymetazoline
  • Phenylpropanolamine
  • Piperoxan
  • Pseudoephedrine
  • Rezatomidine
  • Rilmenidine
  • Romifidine
  • Talipexole
  • Tasipimidine
  • Tetrahydrozoline
  • Tiamenidine
  • Tizanidine
  • Tolonidine
  • Urapidil
  • Vatinoxan
  • XP21279
  • Xylazine
  • Xylometazoline
  • Antagonists: 1-PP
  • Adimolol
  • Amesergide
  • Aptazapine
  • Atipamezole
  • Atypical antipsychotics (e.g., asenapine , brexpiprazole , clozapine , lurasidone , paliperidone , quetiapine , risperidone , zotepine )
  • Azapirones (e.g., buspirone , gepirone , ipsapirone , tandospirone )
  • BRL-44408
  • Buflomedil
  • Cirazoline
  • Efaroxan
  • Esmirtazapine
  • Fenmetozole
  • Fluparoxan
  • Idazoxan
  • mCPP
  • Mianserin
  • Mirtazapine
  • NAN-190
  • Olanzapine
  • Pardoprunox
  • Phentolamine
  • Phenoxybenzamine
  • Piperoxan
  • Piribedil
  • Rauwolscine
  • Rotigotine
  • SB-269970
  • Setiptiline
  • Spiroxatrine
  • Sunepitron
  • Tolazoline
  • Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )
  • Yohimbine
β
  • Agonists: Abediterol
  • Alifedrine
  • Amibegron
  • Arbutamine
  • Arformoterol
  • Arotinolol
  • BAAM
  • Bambuterol
  • Befunolol
  • Bitolterol
  • Broxaterol
  • Buphenine
  • Carbuterol
  • Carmoterol
  • Cimaterol
  • Clenbuterol
  • Colterol
  • Corbadrine
  • Denopamine
  • Dipivefrine
  • Dobutamine
  • Dopamine
  • Dopexamine
  • Droxidopa (L-DOPS)
  • Ephedrine
  • Epinephrine
  • Etafedrine
  • Etilefrine
  • Etilevodopa
  • Ethylnorepinephrine
  • Fenoterol
  • Formoterol
  • Hexoprenaline
  • Higenamine
  • Indacaterol
  • Isoetarine
  • Isoprenaline
  • Isoxsuprine
  • L-DOPA (levodopa)
  • L-Phenylalanine
  • L-Tyrosine
  • Levosalbutamol
  • Mabuterol
  • Melevodopa
  • Methoxyphenamine
  • Methyldopa
  • Mirabegron
  • Norepinephrine
  • Orciprenaline
  • Oxyfedrine
  • PF-610355
  • Phenylpropanolamine
  • Pirbuterol
  • Prenalterol
  • Ractopamine
  • Procaterol
  • Pseudoephedrine
  • Reproterol
  • Rimiterol
  • Ritodrine
  • Salbutamol
  • Salmeterol
  • Solabegron
  • Terbutaline
  • Tretoquinol
  • Tulobuterol
  • Vilanterol
  • Xamoterol
  • XP21279
  • Zilpaterol
  • Zinterol
  • Antagonists: Acebutolol
  • Adaprolol
  • Adimolol
  • Afurolol
  • Alprenolol
  • Alprenoxime
  • Amosulalol
  • Ancarolol
  • Arnolol
  • Arotinolol
  • Atenolol
  • Befunolol
  • Betaxolol
  • Bevantolol
  • Bisoprolol
  • Bopindolol
  • Bornaprolol
  • Brefonalol
  • Bucindolol
  • Bucumolol
  • Bufetolol
  • Bufuralol
  • Bunitrolol
  • Bunolol
  • Bupranolol
  • Butaxamine
  • Butidrine
  • Butofilolol
  • Capsinolol
  • Carazolol
  • Carpindolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Cetamolol
  • Cicloprolol
  • Cinamolol
  • Cloranolol
  • Cyanopindolol
  • Dalbraminol
  • Dexpropranolol
  • Diacetolol
  • Dichloroisoprenaline
  • Dihydroalprenolol
  • Dilevalol
  • Diprafenone
  • Draquinolol
  • Ecastolol
  • Epanolol
  • Ericolol
  • Ersentilide
  • Esatenolol
  • Esprolol
  • Eugenodilol
  • Exaprolol
  • Falintolol
  • Flestolol
  • Flusoxolol
  • Hydroxycarteolol
  • Hydroxytertatolol
  • ICI-118,551
  • Idropranolol
  • Indenolol
  • Indopanolol
  • Iodocyanopindolol
  • Iprocrolol
  • Isoxaprolol
  • Isamoltane
  • Labetalol
  • Landiolol
  • Levobetaxolol
  • Levobunolol
  • Levomoprolol
  • Medroxalol
  • Mepindolol
  • Metipranolol
  • Metoprolol
  • Moprolol
  • Nadolol
  • Nadoxolol
  • Nebivolol
  • Nifenalol
  • Nipradilol
  • Oxprenolol
  • Pacrinolol
  • Pafenolol
  • Pamatolol
  • Pargolol
  • Penbutolol
  • Pindolol
  • Practolol
  • Primidolol
  • Procinolol
  • Pronethalol
  • Propafenone
  • Propranolol
  • Ridazolol
  • Ronactolol
  • Soquinolol
  • Sotalol
  • Spirendolol
  • SR 59230A
  • Sulfinalol
  • Talinolol
  • Tazolol
  • Tertatolol
  • Tienoxolol
  • Tilisolol
  • Timolol
  • Tiprenolol
  • Tolamolol
  • Toliprolol
  • Xibenolol
  • Xipranolol
  • v
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  • e
Histamine receptor modulators
H1
  • Agonists: 2-Pyridylethylamine
  • Betahistine
  • Histamine
  • HTMT
  • L-Histidine
  • UR-AK49
  • Antagonists: First-generation: 4-Methyldiphenhydramine
  • Alimemazine
  • Antazoline
  • Azatadine
  • Bamipine
  • Benzatropine (benztropine)
  • Bepotastine
  • Bromazine
  • Brompheniramine
  • Buclizine
  • Captodiame
  • Carbinoxamine
  • Chlorcyclizine
  • Chloropyramine
  • Chlorothen
  • Chlorphenamine
  • Chlorphenoxamine
  • Cinnarizine
  • Clemastine
  • Clobenzepam
  • Clocinizine
  • Cloperastine
  • Cyclizine
  • Cyproheptadine
  • Dacemazine
  • Decloxizine
  • Deptropine
  • Dexbrompheniramine
  • Dexchlorpheniramine
  • Dimenhydrinate
  • Dimetindene
  • Diphenhydramine
  • Diphenylpyraline
  • Doxylamine
  • Embramine
  • Etodroxizine
  • Etybenzatropine (ethylbenztropine)
  • Etymemazine
  • Fenethazine
  • Flunarizine
  • Histapyrrodine
  • Homochlorcyclizine
  • Hydroxyethylpromethazine
  • Hydroxyzine
  • Isopromethazine
  • Isothipendyl
  • Meclozine
  • Medrylamine
  • Mepyramine (pyrilamine)
  • Mequitazine
  • Methafurylene
  • Methapyrilene
  • Methdilazine
  • Moxastine
  • Orphenadrine
  • Oxatomide
  • Oxomemazine
  • Perlapine
  • Phenindamine
  • Pheniramine
  • Phenyltoloxamine
  • Pimethixene
  • Piperoxan
  • Pipoxizine
  • Promethazine
  • Propiomazine
  • Pyrrobutamine
  • Talastine
  • Thenalidine
  • Thenyldiamine
  • Thiazinamium
  • Thonzylamine
  • Tolpropamine
  • Tripelennamine
  • Triprolidine
  • Second/third-generation: Acrivastine
  • Alinastine
  • Astemizole
  • Azelastine
  • Bamirastine
  • Barmastine
  • Bepiastine
  • Bepotastine
  • Bilastine
  • Cabastinen
  • Carebastine
  • Cetirizine
  • Clemastine
  • Clemizole
  • Clobenztropine
  • Desloratadine
  • Dorastine
  • Ebastine
  • Efletirizine
  • Emedastine
  • Epinastine
  • Fexofenadine
  • Flezelastine
  • Ketotifen
  • Latrepirdine
  • Levocabastine
  • Levocetirizine
  • Linetastine
  • Loratadine
  • Mapinastine
  • Mebhydrolin
  • Mizolastine
  • Moxastine
  • Noberastine
  • Octastine
  • Olopatadine
  • Perastine
  • Pibaxizine
  • Piclopastine
  • Quifenadine (phencarol)
  • Rocastine
  • Rupatadine
  • Setastine
  • Sequifenadine (bicarphen)
  • Talastine
  • Temelastine
  • Terfenadine
  • Vapitadine
  • Zepastine
  • Others: Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , clozapine , iloperidone , olanzapine , paliperidone , quetiapine , risperidone , RP-5063 , ziprasidone , zotepine )
  • Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )
  • Tetracyclic antidepressants (e.g., amoxapine , loxapine , maprotiline , mianserin , mirtazapine , oxaprotiline )
  • Tricyclic antidepressants (e.g., amitriptyline , butriptyline , clomipramine , desipramine , dosulepin (dothiepin) , doxepin , imipramine , iprindole , lofepramine , nortriptyline , protriptyline , trimipramine )
  • Typical antipsychotics (e.g., chlorpromazine , flupenthixol , fluphenazine , loxapine , perphenazine , prochlorperazine , thioridazine , thiothixene )
  • Unknown/unsorted: Azanator
  • Belarizine
  • Elbanizine
  • Flotrenizine
  • GSK1004723
  • Napactadine
  • Tagorizine
  • Trelnarizine
  • Trenizine
H2
  • Agonists: Amthamine
  • Betazole
  • Dimaprit
  • Histamine
  • HTMT
  • Impromidine
  • L-Histidine
  • UR-AK49
  • Antagonists: Bisfentidine
  • Burimamide
  • Cimetidine
  • Dalcotidine
  • Donetidine
  • Ebrotidine
  • Etintidine
  • Famotidine
  • Isolamtidine
  • Lafutidine
  • Lamtidine
  • Lavoltidine (loxtidine)
  • Lupitidine
  • Metiamide
  • Mifentidine
  • Niperotidine
  • Nizatidine
  • Osutidine
  • Oxmetidine
  • Pibutidine
  • Quisultazine (quisultidine)
  • Ramixotidine
  • Ranitidine
  • Roxatidine
  • Sufotidine
  • Tiotidine
  • Tuvatidine
  • Venritidine
  • Xaltidine
  • Zolantidine
H3
  • Agonists: α-Methylhistamine
  • Cipralisant
  • Histamine
  • Imetit
  • Immepip
  • Immethridine
  • L-Histidine
  • Methimepip
  • Proxyfan
  • Antagonists: A-349,821
  • A-423,579
  • ABT-239
  • ABT-652
  • AZD5213
  • Bavisant
  • Betahistine
  • Burimamide
  • Ciproxifan
  • Clobenpropit
  • Conessine
  • Enerisant
  • GSK-189,254
  • Impentamine
  • Iodophenpropit
  • Irdabisant
  • JNJ-5207852
  • MK-0249
  • NNC 38-1049
  • PF-03654746
  • Pitolisant
  • SCH-79687
  • Thioperamide
  • VUF-5681
H4
  • Agonists: 4-Methylhistamine
  • α-Methylhistamine
  • Histamine
  • L-Histidine
  • OUP-16
  • VUF-8430
  • Antagonists: JNJ-7777120
  • Mianserin
  • Seliforant
  • Thioperamide
  • Toreforant
  • VUF-6002
See also: Receptor/signaling modulators • Monoamine metabolism modulators • Monoamine reuptake inhibitors
  • v
  • t
  • e
Monoamine reuptake inhibitors
DAT
( DRIs )
  • Piperazines: DBL-583
  • GBR-12783
  • GBR-12935
  • GBR-13069
  • GBR-13098
  • Nefazodone
  • Vanoxerine
  • Piperidines: 4-Fluoropethidine
  • Benocyclidine (BTCP)
  • Desoxypipradrol
  • Dexmethylphenidate
  • Difemetorex
  • Ethylphenidate
  • HDMP-28
  • Methylphenidate
  • Pethidine (meperidine)
  • Phencyclidine
  • Pipradrol
  • Tenocyclidine
  • Pyrrolidines: Diphenylprolinol
  • MDPV
  • Naphyrone
  • Prolintane
  • Pyrovalerone
  • Tropanes: Altropane
  • Benzatropine (benztropine)
  • Brasofensine
  • CFT
  • Cocaine
  • Dichloropane
  • Difluoropine
  • Etybenzatropine (ethybenztropine)
  • FE-β-CPPIT
  • FP-β-CPPIT
  • Ioflupane (123I)
  • RTI-55
  • RTI-112
  • RTI-113
  • RTI-121
  • RTI-126
  • RTI-150
  • RTI-177
  • RTI-229
  • RTI-336
  • Tesofensine
  • Troparil
  • Tropoxane
  • WF-11
  • WF-23
  • WF-31
  • WF-33
  • Others: Adrafinil
  • Amifitadine
  • Armodafinil
  • Amfonelic acid
  • Amineptine
  • Ansofaxine
  • BTQ
  • BTS 74,398
  • Bupropion
  • Chaenomeles speciosa
  • Ciclazindol
  • Dasotraline
  • Desmethylsertraline
  • Desmethylsibutramine
  • Diclofensine
  • Didesmethylsibutramine
  • Dimethocaine
  • Diphenylpyraline
  • Dizocilpine (MK-801)
  • DOV-102,677
  • DOV-216,303
  • Efavirenz
  • Ephenidine
  • Esketamine
  • EXP-561
  • Fencamfamin
  • Fezolamine
  • Fluorenol
  • GYKI-52895
  • Indatraline
  • Ketamine
  • Lefetamine
  • Levophacetoperane
  • Liafensine
  • LR-5182
  • Manifaxine
  • Mazindol
  • Medifoxamine
  • Mesocarb
  • Metaphit
  • MIN-117 (WF-516)
  • Modafinil
  • Nefopam
  • Nomifensine
  • NS-2359
  • O-2172
  • Oroxylin A
  • Perafensine
  • Pridefine
  • Radafaxine
  • Rimcazole
  • Sertraline
  • Sibutramine
  • Solriamfetol
  • Tametraline
  • Tedatioxetine
  • Tripelennamine
  • Venlafaxine
NET
( NRIs )
  • Selective norepinephrine reuptake inhibitors: Amedalin
  • Alseroxylon
  • Ciclazindol
  • Daledalin
  • Edivoxetine
  • Esreboxetine
  • Lortalamine
  • Mazindol
  • Nisoxetine
  • Reboxetine
  • Talopram
  • Talsupram
  • Tandamine
  • Teniloxazine
  • Viloxazine
  • Norepinephrine–dopamine reuptake inhibitors: Amineptine
  • Bupropion
  • Fencamine
  • Fencamfamin
  • Hydroxybupropion
  • Lefetamine
  • Levophacetoperane
  • LR-5182
  • Manifaxine
  • Methylphenidate
  • Nomifensine
  • O-2172
  • Radafaxine
  • Solriamfetol
  • Serotonin–norepinephrine reuptake inhibitors: Atomoxetine (tomoxetine)
  • BTS-54505
  • CP-39,332
  • Desvenlafaxine
  • Duloxetine
  • Eclanamine
  • Levomilnacipran
  • McN-5652
  • Milnacipran
  • N-Methyl-PPPA
  • Nafenodone
  • PPPA
  • Tofenacin
  • Venlafaxine
  • WY-45233
  • Serotonin–norepinephrine–dopamine reuptake inhibitors: 3,3-Diphenylcyclobutanamine
  • Amifitadine
  • Ansofaxine
  • Bicifadine
  • Brasofensine
  • Centanafadine
  • Cocaine
  • Dasotraline
  • Desmethylsertraline
  • Desmethylsibutramine
  • Diclofensine
  • Didesmethylsibutramine
  • DOV-102677
  • DOV-216303
  • EXP-561
  • Fezolamine
  • HDMP-28
  • Indatraline
  • JNJ-7925476
  • JZ-IV-10
  • Liafensine
  • Mazindol
  • Naphyrone
  • Nefazodone
  • Nefopam
  • NS-2359
  • Perafensine
  • PRC200
  • Pridefine
  • SEP-228431
  • SEP-228432
  • Sibutramine
  • Tedatioxetine
  • Tesofensine
  • Tropanes (e.g., cocaine )
  • Tricyclic antidepressants: Amitriptyline
  • Butriptyline
  • Cianopramine
  • Clomipramine
  • Desipramine
  • Dosulepin (dothiepin)
  • Doxepin
  • Imipramine
  • Lofepramine
  • Melitracen
  • Nortriptyline
  • Protriptyline
  • Trimipramine
  • Tetracyclic antidepressants: Amoxapine
  • Maprotiline
  • Mianserin
  • Oxaprotiline
  • Setiptiline
  • Others: Antihistamines (e.g., brompheniramine , chlorphenamine , pheniramine , tripelennamine )
  • Antipsychotics (e.g., loxapine , ziprasidone )
  • Arylcyclohexylamines (e.g., ketamine , phencyclidine )
  • Dopexamine
  • Ephenidine
  • Ginkgo biloba
  • Indeloxazine
  • Nefazodone
  • Opioids (e.g., desmetramadol , methadone , pethidine (meperidine) , tapentadol , tramadol , levorphanol )
SERT
( SRIs )
  • Selective serotonin reuptake inhibitors: Alaproclate
  • Centpropazine
  • Cericlamine
  • Citalopram
  • Dapoxetine
  • Desmethylcitalopram
  • Didesmethylcitalopram
  • Escitalopram
  • Femoxetine
  • Fluoxetine
  • Fluvoxamine
  • Indalpine
  • Ifoxetine
  • Norfluoxetine
  • Omiloxetine
  • Panuramine
  • Paroxetine
  • PIM-35
  • Pirandamine
  • RTI-353
  • Seproxetine
  • Sertraline
  • Zimelidine
  • Selective serotonin reuptake inhibitors and serotonin receptor modulators: Etoperidone
  • Litoxetine
  • Lubazodone
  • LY-393558
  • SB-649915
  • TGBA01AD
  • Trazodone
  • Vilazodone
  • Vortioxetine
  • Serotonin–norepinephrine reuptake inhibitors: Atomoxetine (tomoxetine)
  • Bicifadine
  • BTS-54505
  • CP-39332
  • Desvenlafaxine
  • Duloxetine
  • Eclanamine
  • Levomilnacipran
  • McN-5652
  • Milnacipran
  • N-Methyl-PPPA
  • PPPA
  • Tofenacin
  • Venlafaxine
  • WY-45233
  • Serotonin–norepinephrine–dopamine reuptake inhibitors: 3,3-Diphenylcyclobutanamine
  • Amifitadine
  • Ansofaxine
  • Bicifadine
  • Brasofensine
  • Centanafadine
  • Cocaine
  • Dasotraline
  • Desmethylsertraline
  • Desmethylsibutramine
  • Diclofensine
  • Didesmethylsibutramine
  • DOV-102677
  • DOV-216303
  • EXP-561
  • Fezolamine
  • HDMP-28
  • Indatraline
  • JNJ-7925476
  • JZ-IV-10
  • Liafensine
  • Mazindol
  • Naphyrone
  • Nefazodone
  • Nefopam
  • NS-2359
  • Perafensine
  • PRC200
  • Pridefine
  • SEP-228431
  • SEP-228432
  • Sibutramine
  • Tedatioxetine
  • Tesofensine
  • Tropanes (e.g., cocaine )
  • Tricyclic antidepressants: Amitriptyline
  • Cianopramine
  • Clomipramine
  • Cyanodothiepin
  • Desipramine
  • Dosulepin (dothiepin)
  • Doxepin
  • Imipramine
  • Lofepramine
  • Nortriptyline
  • Pipofezine
  • Protriptyline
  • Others: A-80426
  • Amoxapine
  • Antihistamines (e.g., brompheniramine , chlorphenamine , dimenhydrinate , diphenhydramine , mepyramine (pyrilamine) , pheniramine , tripelennamine )
  • Antipsychotics (e.g., loxapine , ziprasidone )
  • Arylcyclohexylamines (e.g., 3-MeO-PCP , esketamine , ketamine , methoxetamine , phencyclidine )
  • Cyclobenzaprine
  • Delucemine
  • Dextromethorphan
  • Dextrorphan
  • Efavirenz
  • Medifoxamine
  • Mesembrine
  • Mifepristone
  • MIN-117 (WF-516)
  • N-Me-5-HT
  • Opioids (e.g., dextropropoxyphene , methadone , pethidine (meperidine) , levorphanol , tapentadol , tramadol )
  • Roxindole
VMATs
  • Amiodarone
  • Amphetamines (e.g., amphetamine , methamphetamine , MDMA )
  • APP
  • AZIK
  • Bietaserpine
  • Deserpidine
  • Deutetrabenazine
  • Dihydrotetrabenazine
  • Efavirenz
  • GBR-12935
  • GZ-793A
  • Ibogaine
  • Ketanserin
  • Lobeline
  • Methoxytetrabenazine
  • Reserpine
  • Rose bengal
  • Tetrabenazine
  • Valbenazine
  • Vanoxerine (GBR-12909)
Others
  • DAT enhancers: Luteolin
  • DAT modulators: Agonist-like: SoRI-9804
  • SoRI-20040 ; Antagonist-like: SoRI-20041
See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins
  • v
  • t
  • e
Serotonin receptor modulators
5-HT1
5-HT1A
  • Agonists: 8-OH-DPAT
  • Adatanserin
  • Amphetamine
  • Antidepressants (e.g., etoperidone , hydroxynefazodone , nefazodone , trazodone , triazoledione , vilazodone , vortioxetine )
  • Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , cariprazine , clozapine , lurasidone , quetiapine , ziprasidone )
  • Azapirones (e.g., buspirone , eptapirone , gepirone , perospirone , tandospirone )
  • Bay R 1531
  • Befiradol
  • BMY-14802
  • Cannabidiol
  • Dimemebfe
  • Dopamine
  • Ebalzotan
  • Eltoprazine
  • Enciprazine
  • Ergolines (e.g., bromocriptine , cabergoline , dihydroergotamine , ergotamine , lisuride , LSD , methylergometrine (methylergonovine) , methysergide , pergolide )
  • F-11461
  • F-12826
  • F-13714
  • F-14679
  • F-15063
  • F-15599
  • Flesinoxan
  • Flibanserin
  • Flumexadol
  • Lesopitron
  • LY-293284
  • LY-301317
  • mCPP
  • MKC-242
  • Naluzotan
  • NBUMP
  • Osemozotan
  • Oxaflozane
  • Pardoprunox
  • Piclozotan
  • Rauwolscine
  • Repinotan
  • Roxindole
  • RU-24969
  • S-14506
  • S-14671
  • S-15535
  • Sarizotan
  • Serotonin (5-HT)
  • SSR-181507
  • Sunepitron
  • Tryptamines (e.g., 5-CT , 5-MeO-DMT , 5-MT , bufotenin , DMT , indorenate , N-Me-5-HT , psilocin , psilocybin )
  • TGBA01AD
  • U-92016A
  • Urapidil
  • Vilazodone
  • Xaliproden
  • Yohimbine
  • Antagonists: Atypical antipsychotics (e.g., iloperidone , risperidone , sertindole )
  • AV965
  • Beta blockers (e.g., alprenolol , carteolol , cyanopindolol , iodocyanopindolol , isamoltane , oxprenolol , penbutolol , pindobind , pindolol , propranolol , tertatolol )
  • BMY-7378
  • CSP-2503
  • Dotarizine
  • Ergolines (e.g., metergoline )
  • Flopropione
  • GR-46611
  • Isamoltane
  • Lecozotan
  • Mefway
  • Metitepine (methiothepin)
  • MIN-117 (WF-516)
  • MPPF
  • NAN-190
  • Robalzotan
  • S-15535
  • SB-649915
  • SDZ 216-525
  • Spiperone
  • Spiramide
  • Spiroxatrine
  • UH-301
  • WAY-100135
  • WAY-100635
  • Xylamidine
  • Unknown/unsorted: Acetryptine
  • Ergolines (e.g., ergometrine (ergonovine) )
5-HT1B
  • Agonists: CGS-12066A
  • CP-93129
  • CP-94253
  • CP-122,288
  • CP-135807
  • Eltoprazine
  • Ergolines (e.g., bromocriptine , dihydroergotamine , ergotamine , methylergometrine (methylergonovine) , methysergide , pergolide )
  • mCPP
  • RU-24969
  • Serotonin (5-HT)
  • Triptans (e.g., avitriptan , donitriptan , eletriptan , sumatriptan , zolmitriptan )
  • TFMPP
  • Tryptamines (e.g., 5-BT , 5-CT , 5-MT , DMT )
  • Vortioxetine
  • Antagonists: AR-A000002
  • Beta blockers (e.g., alprenolol , carteolol , isamoltane , oxprenolol , penbutolol , propranolol , tertatolol )
  • Elzasonan
  • Ergolines (e.g., metergoline )
  • GR-127935
  • Isamoltane
  • LY-393558
  • Metitepine (methiothepin)
  • SB-216641
  • SB-224289
  • SB-236057
  • Yohimbine
  • Unknown/unsorted: Ergolines (e.g., cabergoline , ergometrine (ergonovine) , lisuride )
5-HT1D
  • Agonists: CP-122,288
  • CP-135807
  • CP-286601
  • Ergolines (e.g., bromocriptine , cabergoline , dihydroergotamine , ergotamine , LSD , methysergide )
  • GR-46611
  • L-694247
  • L-772405
  • mCPP
  • PNU-109291
  • PNU-142633
  • Serotonin (5-HT)
  • TGBA01AD
  • Triptans (e.g., almotriptan , avitriptan , donitriptan , eletriptan , frovatriptan , naratriptan , rizatriptan , sumatriptan , zolmitriptan )
  • Tryptamines (e.g., 5-BT , 5-CT , 5-Et-DMT , 5-MT , 5-(nonyloxy)tryptamine , DMT )
  • Antagonists: Alniditan
  • BRL-15572
  • Elzasonan
  • Ergolines (e.g., metergoline )
  • GR-127935
  • Ketanserin
  • LY-310762
  • LY-367642
  • LY-393558
  • LY-456219
  • LY-456220
  • Metitepine (methiothepin)
  • Mianserin
  • Ritanserin
  • Yohimbine
  • Ziprasidone
  • Unknown/unsorted: Acetryptine
  • Ergolines (e.g., lisuride , lysergol , pergolide )
5-HT1E
  • Agonists: BRL-54443
  • Ergolines (e.g., methysergide )
  • Serotonin (5-HT)
  • Triptans (e.g., eletriptan )
  • Tryptamines (e.g., tryptamine )
  • Antagonists: Metitepine (methiothepin)
  • Unknown/unsorted: Ergolines (e.g., ergometrine (ergonovine) , lysergol , methylergometrine (methylergonovine)
5-HT1F
  • Agonists: BRL-54443
  • CP-122,288
  • Ergolines (e.g., bromocriptine , lysergol , methylergometrine (methylergonovine) methysergide )
  • Lasmiditan
  • LY-334370
  • Serotonin (5-HT)
  • Triptans (e.g., eletriptan , naratriptan , sumatriptan )
  • Tryptamines (e.g., 5-MT )
  • Antagonists: Mianserin
  • Metitepine (methiothepin)
5-HT2
5-HT2A
  • Agonists: 25H/NB series (e.g., 25I-NBF , 25I-NBMD , 25I-NBOH , 25I-NBOMe , 25B-NBOMe , 25C-NBOMe , 25TFM-NBOMe , 2CBCB-NBOMe , 25CN-NBOH , 2CBFly-NBOMe )
  • 2Cs (e.g., 2C-B , 2C-E , 2C-I , 2C-T-2 , 2C-T-7 , 2C-T-21 )
  • 2C-B-FLY
  • 2CB-Ind
  • 5-Methoxytryptamines ( 5-MeO-DET , 5-MeO-DiPT , 5-MeO-DMT , 5-MeO-DPT , 5-MT )
  • α-Alkyltryptamines (e.g., 5-Cl-αMT , 5-Fl-αMT , 5-MeO-αET , 5-MeO-αMT , α-Me-5-HT , αET , αMT )
  • AL-34662
  • AL-37350A
  • Bromo-DragonFLY
  • Dimemebfe
  • DMBMPP
  • DOx (e.g., DOB , DOC , DOI , DOM )
  • Efavirenz
  • Ergolines (e.g., 1P-LSD , ALD-52 , bromocriptine , cabergoline , ergine (LSA) , ergometrine (ergonovine) , ergotamine , lisuride , LA-SS-Az , LSB , LSD , LSD-Pip , LSH , LSP , methylergometrine (methylergonovine) , pergolide )
  • Flumexadol
  • Jimscaline
  • Lorcaserin
  • MDxx (e.g., MDA (tenamfetamine) , MDMA (midomafetamine) , MDOH , MMDA )
  • O-4310
  • Oxaflozane
  • PHA-57378
  • PNU-22394
  • PNU-181731
  • RH-34
  • Phenethylamines (e.g., lophophine , mescaline )
  • Piperazines (e.g., BZP , quipazine , TFMPP )
  • Serotonin (5-HT)
  • TCB-2
  • TFMFly
  • Tryptamines (e.g., 5-BT , 5-CT , bufotenin , DET , DiPT , DMT , DPT , psilocin , psilocybin , tryptamine )
  • Antagonists: 5-I-R91150
  • 5-MeO-NBpBrT
  • AC-90179
  • Adatanserin
  • Altanserin
  • Antihistamines (e.g., cyproheptadine , hydroxyzine , ketotifen , perlapine )
  • AMDA
  • Atypical antipsychotics (e.g., amperozide , aripiprazole , asenapine , blonanserin , brexpiprazole , carpipramine , clocapramine , clorotepine , clozapine , fluperlapine , gevotroline , iloperidone , lurasidone , melperone , mosapramine , ocaperidone , olanzapine , paliperidone , quetiapine , risperidone , sertindole , zicronapine , ziprasidone , zotepine )
  • Cinanserin
  • CSP-2503
  • Deramciclane
  • Dotarizine
  • Eplivanserin
  • Ergolines (e.g., amesergide , LY-53857 , LY-215840 , mesulergine , metergoline , methysergide , sergolexole )
  • Fananserin
  • Flibanserin
  • Glemanserin
  • Irindalone
  • Ketanserin
  • KML-010
  • Landipirdine
  • LY-393558
  • mCPP
  • Medifoxamine
  • Metitepine (methiothepin)
  • MIN-117 (WF-516)
  • Naftidrofuryl
  • Nantenine
  • Nelotanserin
  • Opiranserin (VVZ-149)
  • Pelanserin
  • Phenoxybenzamine
  • Pimavanserin
  • Pirenperone
  • Pizotifen
  • Pruvanserin
  • Rauwolscine
  • Ritanserin
  • Roluperidone
  • S-14671
  • Sarpogrelate
  • Serotonin antagonists and reuptake inhibitors (e.g., etoperidone , hydroxynefazodone , lubazodone , mepiprazole , nefazodone , triazoledione , trazodone )
  • SR-46349B
  • TGBA01AD
  • Teniloxazine
  • Temanogrel
  • Tetracyclic antidepressants (e.g., amoxapine , aptazapine , esmirtazapine , maprotiline , mianserin , mirtazapine )
  • Tricyclic antidepressants (e.g., amitriptyline )
  • Typical antipsychotics (e.g., chlorpromazine , fluphenazine , haloperidol , loxapine , perphenazine , pimozide , pipamperone , prochlorperazine , setoperone , spiperone , spiramide , thioridazine , thiothixene , trifluoperazine )
  • Volinanserin
  • Xylamidine
  • Yohimbine
  • Unknown/unsorted: Ergolines (e.g., dihydroergotamine , nicergoline )
5-HT2B
  • Agonists: 4-Methylaminorex
  • Aminorex
  • Amphetamines (e.g., chlorphentermine , cloforex , dexfenfluramine , fenfluramine , levofenfluramine , norfenfluramine )
  • BW-723C86
  • DOx (e.g., DOB , DOC , DOI , DOM )
  • Ergolines (e.g., cabergoline , dihydroergocryptine , dihydroergotamine , ergotamine , methylergometrine (methylergonovine) , methysergide , pergolide )
  • Lorcaserin
  • MDxx (e.g., MDA (tenamfetamine) , MDMA (midomafetamine) , MDOH , [MMDA (drug)
  • Antagonists: Agomelatine
  • Atypical antipsychotics (e.g., amisulpride , aripiprazole , asenapine , brexpiprazole , cariprazine , clozapine , N-desalkylquetiapine (norquetiapine) , N-desmethylclozapine (norclozapine) , olanzapine , pipamperone , quetiapine , risperidone , ziprasidone )
  • Cyproheptadine
  • EGIS-7625
  • Ergolines (e.g., amesergide , bromocriptine , lisuride , LY-53857 , LY-272015 , mesulergine )
  • Ketanserin
  • LY-393558
  • mCPP
  • Metadoxine
  • Metitepine (methiothepin)
  • Pirenperone
  • Pizotifen
  • Propranolol
  • PRX-08066
  • Rauwolscine
  • Ritanserin
  • RS-127445
  • Sarpogrelate
  • SB-200646
  • SB-204741
  • SB-206553
  • SB-215505
  • SB-221284
  • SB-228357
  • SDZ SER-082
  • Tegaserod
  • Tetracyclic antidepressants (e.g., amoxapine , mianserin , mirtazapine )
  • Trazodone
  • Typical antipsychotics (e.g., chlorpromazine )
  • TIK-301
  • Yohimbine
  • Unknown/unsorted: Ergolines (e.g., ergometrine (ergonovine) )
5-HT2C
  • Agonists: 2Cs (e.g., 2C-B , 2C-E , 2C-I , 2C-T-2 , 2C-T-7 , 2C-T-21 )
  • 5-Methoxytryptamines ( 5-MeO-DET , 5-MeO-DiPT , 5-MeO-DMT , 5-MeO-DPT , 5-MT )
  • α-Alkyltryptamines (e.g., 5-Cl-αMT , 5-Fl-αMT , 5-MeO-αET , 5-MeO-αMT , α-Me-5-HT , αET , αMT )
  • A-372159
  • AL-38022A
  • Alstonine
  • CP-809101
  • Dimemebfe
  • DOx (e.g., DOB , DOC , DOI , DOM )
  • Ergolines (e.g., ALD-52 , cabergoline , dihydroergotamine , ergine (LSA) , ergotamine , lisuride , LA-SS-Az , LSB , LSD , LSD-Pip , LSH , LSP , pergolide )
  • Flumexadol
  • Lorcaserin
  • MDxx (e.g., MDA (tenamfetamine) , MDMA (midomafetamine) , MDOH , MMDA )
  • MK-212
  • Org 12962
  • Org 37684
  • Oxaflozane
  • PHA-57378
  • Phenethylamines (e.g., lophophine , mescaline )
  • Piperazines (e.g., aripiprazole , BZP , mCPP , quipazine , TFMPP )
  • PNU-22394
  • PNU-181731
  • Ro60-0175
  • Ro60-0213
  • Serotonin (5-HT)
  • Tryptamines (e.g., 5-BT , 5-CT , bufotenin , DET , DiPT , DMT , DPT , psilocin , psilocybin , tryptamine )
  • Vabicaserin
  • WAY-629
  • WAY-161503
  • YM-348
  • Antagonists: Adatanserin
  • Agomelatine
  • Atypical antipsychotics (e.g., asenapine , clorotepine , clozapine , fluperlapine , iloperidone , melperone , olanzapine , paliperidone , quetiapine , risperidone , sertindole , ziprasidone , zotepine )
  • Captodiame
  • CEPC
  • Cinanserin
  • Cyproheptadine
  • Deramciclane
  • Desmetramadol
  • Dotarizine
  • Eltoprazine
  • Ergolines (e.g., amesergide , bromocriptine , LY-53857 , LY-215840 , mesulergine , metergoline , methysergide , sergolexole )
  • Etoperidone
  • Fluoxetine
  • FR-260010
  • Irindalone
  • Ketanserin
  • Ketotifen
  • Latrepirdine (dimebolin)
  • Medifoxamine
  • Metitepine (methiothepin)
  • Nefazodone
  • Pirenperone
  • Pizotifen
  • Propranolol
  • Ritanserin
  • RS-102221
  • S-14671
  • SB-200646
  • SB-206553
  • SB-221284
  • SB-228357
  • SB-242084
  • SB-243213
  • SDZ SER-082
  • Tedatioxetine
  • Tetracyclic antidepressants (e.g., amoxapine , aptazapine , esmirtazapine , maprotiline , mianserin , mirtazapine )
  • TIK-301
  • Tramadol
  • Trazodone
  • Tricyclic antidepressants (e.g., amitriptyline , nortriptyline )
  • Typical antipsychotics (e.g., chlorpromazine , loxapine , pimozide , pipamperone , thioridazine )
  • Xylamidine
  • Unknown/unsorted: Efavirenz
  • Ergolines (e.g., ergometrine (ergonovine) , methylergometrine (methylergonovine) )
5-HT3 – 7
5-HT3
  • Agonists: Alcohols (e.g., butanol , ethanol (alcohol) , trichloroethanol )
  • m-CPBG
  • Phenylbiguanide
  • Piperazines (e.g., BZP , mCPP , quipazine )
  • RS-56812
  • Serotonin (5-HT)
  • SR-57227
  • SR-57227A
  • Tryptamines (e.g., 2-Me-5-HT , 5-CT , bufotenidine (5-HTQ) )
  • Volatiles/gases (e.g., halothane , isoflurane , toluene , trichloroethane )
  • YM-31636
  • Antagonists: Alosetron
  • Arazasetron
  • AS-8112
  • Atypical antipsychotics (e.g., clozapine , olanzapine , quetiapine )
  • Azasetron
  • Batanopride
  • Bemesetron (MDL-72222)
  • Bupropion
  • Cilansetron
  • CSP-2503
  • Dazopride
  • Dolasetron
  • Galanolactone
  • Granisetron
  • Hydroxybupropion
  • ICS-205930
  • Lerisetron
  • Memantine
  • Ondansetron
  • Palonosetron
  • Ramosetron
  • Renzapride
  • Ricasetron
  • Tedatioxetine
  • Tetracyclic antidepressants (e.g., amoxapine , mianserin , mirtazapine )
  • Thujone
  • Tropanserin
  • Tropisetron
  • Typical antipsychotics (e.g., loxapine )
  • Volatiles/gases (e.g., nitrous oxide , sevoflurane , xenon )
  • Vortioxetine
  • Zacopride
  • Zatosetron
  • Unknown/unsorted: LY-53857
  • Piperazines (e.g., naphthylpiperazine )
5-HT4
  • Agonists: 5-MT
  • BIMU8
  • Capeserod
  • Cinitapride
  • Cisapride
  • CJ-033466
  • Dazopride
  • Metoclopramide
  • Minesapride
  • Mosapride
  • Prucalopride
  • PRX-03140
  • Renzapride
  • RS-67333
  • RS-67506
  • Serotonin (5-HT)
  • Tegaserod
  • Velusetrag
  • Zacopride
  • Antagonists: GR-113808
  • GR-125487
  • L-Lysine
  • Piboserod
  • RS-39604
  • RS-67532
  • SB-203186
  • SB-204070
5-HT5A
  • Agonists: Ergolines (e.g., 2-Br-LSD (BOL-148) , ergotamine , LSD )
  • Serotonin (5-HT)
  • Tryptamines (e.g., 5-CT )
  • Valerenic Acid
  • Antagonists: Asenapine
  • Latrepirdine (dimebolin)
  • Metitepine (methiothepin)
  • Ritanserin
  • SB-699551
  • Unknown/unsorted: Ergolines (e.g., metergoline , methysergide )
  • Piperazines (e.g., naphthylpiperazine )
5-HT6
  • Agonists: Ergolines (e.g., dihydroergocryptine , dihydroergotamine , ergotamine , lisuride , LSD , mesulergine , metergoline , methysergide )
  • Serotonin (5-HT)
  • Tryptamines (e.g., 2-Me-5-HT , 5-BT , 5-CT , 5-MT , Bufotenin , E-6801 , E-6837 , EMD-386088 , EMDT , LY-586713 , N-Me-5-HT , tryptamine )
  • WAY-181187
  • WAY-208466
  • Antagonists: ABT-354
  • Atypical antipsychotics (e.g., aripiprazole , asenapine , clorotepine , clozapine , fluperlapine , iloperidone , olanzapine , tiospirone )
  • AVN-101
  • AVN-211
  • AVN-322
  • AVN-397
  • BGC20-760
  • BVT-5182
  • BVT-74316
  • Cerlapirdine
  • EGIS-12233
  • GW-742457
  • Idalopirdine
  • Ketanserin
  • Landipirdine
  • Latrepirdine (dimebolin)
  • Metitepine (methiothepin)
  • MS-245
  • PRX-07034
  • Ritanserin
  • Ro 04-6790
  • Ro 63-0563
  • SB-258585
  • SB-271046
  • SB-357134
  • SB-399885
  • SB-742457
  • Tetracyclic antidepressants (e.g., amoxapine , mianserin )
  • Tricyclic antidepressants (e.g., amitriptyline , clomipramine , doxepin , nortriptyline )
  • Typical antipsychotics (e.g., chlorpromazine , loxapine )
  • Unknown/unsorted: Ergolines (e.g., 2-Br-LSD (BOL-148) , bromocriptine , lergotrile , pergolide )
  • Piperazines (e.g., naphthylpiperazine )
5-HT7
  • Agonists: 8-OH-DPAT
  • AS-19
  • Bifeprunox
  • E-55888
  • Ergolines (e.g., LSD )
  • LP-12
  • LP-44
  • RU-24969
  • Sarizotan
  • Serotonin (5-HT)
  • Triptans (e.g., frovatriptan )
  • Tryptamines (e.g., 5-CT , 5-MT , bufotenin , N-Me-5-HT )
  • Antagonists: Atypical antipsychotics (e.g., amisulpride , aripiprazole , asenapine , brexpiprazole , clorotepine , clozapine , fluperlapine , olanzapine , risperidone , sertindole , tiospirone , ziprasidone , zotepine )
  • Butaclamol
  • DR-4485
  • EGIS-12233
  • Ergolines (e.g., 2-Br-LSD (BOL-148) , amesergide , bromocriptine , cabergoline , dihydroergotamine , ergotamine , LY-53857 , LY-215840 , mesulergine , metergoline , methysergide , sergolexole )
  • JNJ-18038683
  • Ketanserin
  • LY-215840
  • Metitepine (methiothepin)
  • Ritanserin
  • SB-258719
  • SB-258741
  • SB-269970
  • SB-656104
  • SB-656104A
  • SB-691673
  • SLV-313
  • SLV-314
  • Spiperone
  • SSR-181507
  • Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin , mirtazapine )
  • Tricyclic antidepressants (e.g., amitriptyline , clomipramine , imipramine )
  • Typical antipsychotics (e.g., acetophenazine , chlorpromazine , chlorprothixene , fluphenazine , loxapine , pimozide )
  • Vortioxetine
  • Unknown/unsorted: Ergolines (e.g., lisuride , pergolide )
  • Piperazines (e.g., naphthylpiperazine )
  • See also: Receptor/signaling modulators
  • Adrenergics
  • Dopaminergics
  • Melatonergics
  • Monoamine reuptake inhibitors and releasing agents
  • Monoamine metabolism modulators
  • Monoamine neurotoxins

Retrieved from ” https://en.wikipedia.org/w/index.php?title=Trazodone&oldid=863176892 ”
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